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    Should Men Get PSA Tested? Yes, But Based On A New Plan
    By Paul Knoepfler | October 10th 2011 10:58 PM | 4 comments | Print | E-mail | Track Comments
    About Paul

    Associate Professor of Cell Biology and Human Anatomy at UC Davis School of Medicine. Long-time stem cell and cancer scientist. Cancer survivor...

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    Should men get PSA tests? Yes, but not the way we do it now.

    The same federal panel that recommended that women in their 40s not get routine mammograms has now come forth with the statement that PSA testing men for detection of prostate cancer should be stopped.

    I think it is not that simple and I still believe in PSA testing, just with changes in how it is done.

    As many of you know, I'm a prostate cancer survivor and now patient advocate, having been diagnosed with a relatively high grade prostate cancer. I'm nearly two years out and doing well so far, having learned some valuable lessons from my cancer despite the horror of the experience. Of course, I don't know what the future holds, but knock on wood I'm optimistic.

    How was my prostate cancer detected? PSA testing at age 42.

    It's hard for me not to be a believer. My cancer was no "watchful waiting" type of cancer.

    Why might studies of tens of thousands of men seemingly show that PSA testing doesn't help save lives?

    Let me explain.

    First, the average age of diagnosis for prostate cancer, usually based on elevated PSA, is around age 70. Whether a man who is 70 gets treatment for prostate cancer or not, his overall mortality rate is pretty high at that age. The window for surgery or other treatments for prostate cancer to increase his life expectancy is very narrow.

    Second, doctors will tell you if you are in the cancer field (probably not if you are an average patient) that for many patients by the time an elevated PSA is detected, some of the time the cancer has already spread yet such spread is not detectable at the time of diagnosis.  That metastatic cancer will not be cured by removing the prostate or irradiating the heck out of it, and it is that metastatic cancer that kills patients.

    Third, paradoxically it is young men who may  be helped the most by PSA testing. What doctors now recommend is PSA testing after age 50, but I believe it is really far more logical to test at age 40. This establishes a baseline and provides guidance for future testing plans. If the test is low at age 40, then perhaps testing every 5  years makes more sense. If the PSA test is high for that age, yearly testing could be done for a period of time. If no increase is evident, the testing interval could be shifted to longer.

    Fourth, dump the arbitrary cutoff of 4.0 ng/ml. It is basically meaningless if you do not take into account the man's age. Men who are around age 40 typically have a PSA around 1.0 or less. Data from PSA testing needs to be interpreted entirely based upon age. A PSA above 1.0 ng/ml for a man of age 40 should be automatically flagged as abnormal, perhaps 2.0 at age 50, etc. 

    Finally, if scientists studied only those patients for whom an elevated PSA led to the detection of a high-grade (say greater than or equal to 7 on the Gleason scale), I am 100% convinced they would find that PSA testing saves the lives of men, particularly young men.

    So I say keep on doing PSA testing, but do the testing not globally and blindly, but in an intelligent, directed manner based on scientifically rigorous criteria. 

    This is a way to save lives but avoid putting men who have low odds of any benefit through unnecessary treatments.


    Comments

    Hank
    Good stuff, though it will be hard to get people to listen.  Doctors recognize they do too many tests but they don't want to get sued so I think we could get the cost of health care back down if we corralled malpractice costs so doctors didn't have to run every test imaginable - and instead adapt some practical parameters like this.
    Want more no-nonsense, independent science? Buy Science Left Behind
    Steve Davis
    "I think we could get the cost of health care back down if we corralled malpractice costs..."
    Exactly Hank, exactly.
    As it is now, we must be deterring many young people from taking up medicine.
    pknoepfler
    Good points! Thanks, guys.
    Paul S. Knoepfler, Ph.D. Associate Professor UC Davis School of Medicine http://www.ipscell.com
    MY HUSBANDS DOCTOR HADN'T RUN A PSA TEST IN SOME YEARS AND WHEN HE DID IT WAS IN THE 243 RANGE. YES, I SAID THE 243 RANGE AND AFTER MANY TESTS AND BONE SCANS THE CANCER HAD SPREAD TO THE BONES. WHO IS AT FAULT FOR THIS ONE? I THOUGHT THAT A PSA TEST WAS AN AUTOMATIC EVERY YEAR AS IS A MAMOGRAM FOR A WOMAN.