In a closed-loop control approach to managing type 1 diabetes, glucose sensors placed under the skin continuously monitor blood sugar levels, triggering the release of insulin from an implantable insulin pump as needed.
The aim of this closed-loop insulin delivery system is improved control of blood glucose levels throughout the day and night. But a new study in adults and adolescents found that mean blood glucose levels remained at safe levels 53-82% of the time, according to the results published in Diabetes Technology&Therapeutics.
Howard Zisser, MD and an international team of researchers representing the Control to Range Study Group measured plasma glucose levels every 15-30 minutes in a group of individuals with type 1 diabetes who participated in the "Control to Range" multinational artificial pancreas study. They monitored the adults and teens over 22 hours, including three meals and periods of day and night.
The authors describe the risks of hypo- and hyperglycemia, the variability between participants, and the differences in daytime/nighttime results, and also propose improvements needed in the design and implementation of closed-loop systems in the article "Multicenter Closed-Loop Insulin Delivery Study Points to Challenges for Keeping Blood Glucose in a Safe Range by a Control Algorithm in Adults and Adolescents with Type 1 Diabetes from Various Sites".
"It appears that we are getting closer to an Artificial Pancreas option for patients with type 1 diabetes," says DTT Editor-in-Chief Satish Garg, MD, Professor of Medicine and Pediatrics at the University of Colorado Denver. "The first version may need to be a hybrid system in which meals and exercise are announced with necessary dose adjustments along with Automatic Threshold Suspend for hypoglycemia."
Citation: Zisser H, Renard E, Kovatchev B, Cobelli C, Avogaro A, Nimri R, Magni L, Buckingham BA, Chase HP, Doyle FJ, Lum J, 'Multicenter Closed-Loop Insulin Delivery Study Points to Challenges for Keeping Blood Glucose in a Safe Range by a Control Algorithm in Adults and Adolescents with Type 1 Diabetes from Various Sites', Diabetes Technology & Therapeutics doi:10.1089/dia.2014.0066.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Reduce Prostate Cancer Risk By Sleeping With Lots Of Women - But Not Men
- Supersonic Laser-Propelled Aircraft Get A Step Closer
- Greenpeace Says Its GMOs Are Better Than Science's GMOs, Still Hates Golden Rice
- Homo Floresiensis: Hobbit Species Continues To Provoke Questions About Human Evolution
- Okay With Disgusting Images? You Vote This Way 95 Percent Of The Time
- This Mid-Term Election Can Have Evolutionary Consequences
- 4 Things Needed To Make The Perfect Cup Of Coffee
- "Most people like average, because average is most predictable - just as frequent words and symmetrical..."
- "Save Lives With Golden Rice..."
- "From Der_Wanderer The common ground of theist and atheist is that both are believers . That is..."
- "The common ground of theist and atheist is that both are believers . That is both from a high level..."
- "I ought to say just that its marvelous! how to buy twitter retweets..."
- What’s so “natural” about “natural crop breeding”?
- Worried you have cancer? Take a Google pill!
- Mars bars for brain health? Not so fast
- Scientists rebuff Center for Food Safety report alleging chemicals in infant soy milk
- When you take your drugs might matter as much as what you’re taking
- Two Oregon papers join most others in urging “no” on mandatory GMO label vote
- Air quality and unconventional oil and gas sites
- Frailty increases kidney transplant recipients' risk of dying prematurely
- Cochrane news: Expectant mothers with epilepsy face tough choices over their medication
- Report: 93 percent of mining, oil & gas, logging, agriculture developments involve inhabited land
- Breast and colorectal cancers remain more aggressive in children