In a closed-loop control approach to managing type 1 diabetes, glucose sensors placed under the skin continuously monitor blood sugar levels, triggering the release of insulin from an implantable insulin pump as needed.
The aim of this closed-loop insulin delivery system is improved control of blood glucose levels throughout the day and night. But a new study in adults and adolescents found that mean blood glucose levels remained at safe levels 53-82% of the time, according to the results published in Diabetes Technology&Therapeutics.
Howard Zisser, MD and an international team of researchers representing the Control to Range Study Group measured plasma glucose levels every 15-30 minutes in a group of individuals with type 1 diabetes who participated in the "Control to Range" multinational artificial pancreas study. They monitored the adults and teens over 22 hours, including three meals and periods of day and night.
The authors describe the risks of hypo- and hyperglycemia, the variability between participants, and the differences in daytime/nighttime results, and also propose improvements needed in the design and implementation of closed-loop systems in the article "Multicenter Closed-Loop Insulin Delivery Study Points to Challenges for Keeping Blood Glucose in a Safe Range by a Control Algorithm in Adults and Adolescents with Type 1 Diabetes from Various Sites".
"It appears that we are getting closer to an Artificial Pancreas option for patients with type 1 diabetes," says DTT Editor-in-Chief Satish Garg, MD, Professor of Medicine and Pediatrics at the University of Colorado Denver. "The first version may need to be a hybrid system in which meals and exercise are announced with necessary dose adjustments along with Automatic Threshold Suspend for hypoglycemia."
Citation: Zisser H, Renard E, Kovatchev B, Cobelli C, Avogaro A, Nimri R, Magni L, Buckingham BA, Chase HP, Doyle FJ, Lum J, 'Multicenter Closed-Loop Insulin Delivery Study Points to Challenges for Keeping Blood Glucose in a Safe Range by a Control Algorithm in Adults and Adolescents with Type 1 Diabetes from Various Sites', Diabetes Technology & Therapeutics doi:10.1089/dia.2014.0066.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- 2004 BL86 - 'Near Miss' Asteroid Even Has Its Own Moon
- Reviews In Physics - A New Journal
- Wiggles: Inconsistencies Undermine Model Reliability For Projecting Decade-To-Decade Warming
- Planet With Rings Found Outside Solar System - And They Are Bigger Than Saturn
- If Abortion Is A Choice Then Sex Selection Abortion Should Remain Legal
- Happy 150th Birthday To Maxwell's Theory Of Electromagnetism
- Drug Culture: Those “Poppers” Might Not Be What You Think
- "Hi T, Thanks for the note on the CMS result on Majorana neutrinos. However this is not surprising..."
- "Excellent Article, sugar has no nutritional value whatsoever, never has & never will. We had fat..."
- "It looks to me like an alien spacecraft. ..."
- "Hello Sven,good questions. Let me give you some possible answers below.1 - the main advantage of..."
- "so boring. we've all heard this already. back to your intermediate level culture studies class..."