Nobel laureate James D. Watson, the co-discoverer of the double-helix structure of DNA, has published a hypothesis on the causation of type 2 diabetes - that diabetes, dementias, cardiovascular disease, and some cancers are linked to a failure to generate sufficient biological oxidants, called reactive oxygen species (ROS).

Watson does not question that pancreatic tissue in people with type 2 diabetes is indeed inflamed. But he does present a novel theory of why. "The fundamental cause, I suggest, is a lack of biological oxidants, not an excess. The prevalent view of type 2 diabetes is that an excess of intracellular oxidation causes inflammation, which in turn kills cells in pancreatic tissue."

Proper function of those cells, it is well understood, is critical for the maintenance of normal blood glucose levels. 

Watson also argues the case for a better understanding of the role of exercise in helping to remedy this deficiency. Doctors have long told patients with incipient type 2 diabetes – those with high blood sugar levels -- to exercise, often before putting them on a well-proven glucose-lowering drug regimen such as Metformin. Exercise seemed to Watson the key to the puzzle: what was it about exercise that served to benefit people with high blood sugar?

There were important clues, he speculated, in the chemistry of oxidation and reduction reactions. The body's cells cannot survive without making both oxidants and antioxidants. "There is a delicate balance" between the two, Watson observes. Physical exercise prompts the body to make large numbers of oxidants – molecules called reactive oxygen species, or ROS. In a cellular organ called the endoplasmic reticulum (ER), one such "species," the oxidant hydrogen peroxide (H2O2), helps forge chemical bonds (disulfide bonds) which stabilize proteins as they fold.

When there is not enough oxidation in the ER, Watson says, proteins emerge unfolded, and cannot function. This, he proposes, causes the inflammation that harms the pancreas, sometimes causing type 2 diabetes. Hence, Watson suggests, exercise, which promotes oxidation, plausibly can have a beneficial effect on those with high blood sugar. Such benefit would be lessened if not abolished, he speculates, if such an individual consumed large quantities of antioxidants – just as athletes who take large quantities of antioxidant supplements do not seem to benefit or benefit less from their exertions.

Watson has two take-home messages for his audience. "The first is that we sorely need to take a much more serious and thorough scientific look at the mechanisms through which exercise improves our health." Watson is planning a scientific meeting at Cold Spring Harbor Laboratory later this year which he hopes will launch a larger scientific effort.

There is a second message. "I am not a physician and I cannot offer advice about how people should treat their diabetes; I am advancing a novel idea about how type 2 diabetes can occur. But I also note that just about every doctor I've ever known tells every patient who is capable of doing so to exercise. I think exercise helps us produce healthy, functional proteins. But we really need to have some high quality research to demonstrate this."



Citation: James D Watson, 'Type 2 diabetes as a redox disease', The Lancet, Volume 383, Issue 9919, Pages 841 - 843, 1 March 2014 
doi:10.1016/S0140-6736(13)62365-X. Source: Cold Spring Harbor Laboratory