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    Prostate Cancer Biomarkers In Seminal Fluid More Accurate Than PSA
    By News Staff | June 6th 2014 10:51 AM | Print | E-mail | Track Comments

    A new study finds that seminal fluid - semen - contains biomarkers for prostate cancer, the most common cancer in men. 

    University of Adelaide research fellow and lead author Dr Luke Selth says the commonly used PSA (prostate specific antigen) test is by itself not ideal to test for the cancer.
    But the results in Endocrine-Related Cancer show that their new test finds presence of certain molecules in seminal fluid and indicates not only whether a man has prostate cancer, but also the severity of the cancer.

    "While the PSA test is very sensitive, it is not highly specific for prostate cancer," Selth says. "This results in many unnecessary biopsies of non-malignant disease. More problematically, PSA testing has resulted in substantial over-diagnosis and over-treatment of slow growing, non-lethal prostate cancers that could have been safely left alone.

    "Biomarkers that can accurately detect prostate cancer at an early stage and identify aggressive tumors are urgently needed to improve patient care. Identification of such biomarkers is a major focus of our research." 

    Using samples from 60 men, Selth and colleagues discovered a number of small ribonucleic acid (RNA) molecules called microRNAs in seminal fluid that are known to be increased in prostate tumors. The study showed that some of these microRNAs were surprisingly accurate in detecting cancer.

    "The presence of these microRNAs enabled us to more accurately discriminate between patients who had cancer and those who didn't, compared with a standard PSA test," Dr Selth says. "We also found that the one specific microRNA, miR-200b, could distinguish between men with low grade and higher grade tumors. This is important because, as a potential prognostic tool, it will help to indicate the urgency and type of treatment required."

    This research builds on previous work in the British Journal of Cancer, which demonstrated that microRNAs in the blood can predict men who are likely to relapse after surgical removal of their prostate cancer. "We are excited by the potential clinical application of microRNAs in a range of body fluids," he says.