Synthetic Genomics announceda multi-year research and development agreement with Lung Biotechnology to develop humanized pig organs using synthetic genomic advances. The collaboration will focus upon developing organs for human patients in need of transplantation, with an initial focus on lung diseases.
In the United States alone, about 400,000 people die annually from various forms of lung disease including cancer. 2,000 people are saved with a lung transplant and about the same number are added to the transplant wait list annually. 99% of deaths due to lung failure are unavoidable because of the shortage of transplantable human lungs.
Previous attempts to use animal organs have failed due to genomic incompatibilities, especially with respect to immune and coagulation systems. The collaboration between Synthetic Genomics and Lung Biotechnology aims to eliminate these genomic incompatibilities.
Using DNA design, DNA synthesis and genome editing, as well as genome modification tools,
will develop engineered primary pig cells with modified genomes. This work will entail modification of a substantial number of genes at an unprecedented scale and efficiency. United Therapeutics, parent company of Lung Biotechnology, will leverage its xenotransplantation expertise to implant these engineered cells, generating pig embryos which develop and are born with humanized lungs. The companies are striving to develop these new methods and advances to create organs that are safe and effective for use in humans.
Lung Biotechnology made a $50,000,000 investment in Synthetic Genomics.
"We believe that our proprietary synthetic genomic tools and technologies, coupled with United Therapeutics' knowledge and advances in regenerative medicine technologies and treatment of lung diseases, should enable us to develop humanized pig organs for safe and effective transplant into humans. We believe this is one of the most exciting and important programs ever undertaken in modern medical science," said J. Craig Venter, Ph.D., Founder and CEO, SGI.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Getting Married
- Sorry Guardian - You Get An F minus for linguistics
- The Three Cubes Problem
- Debunked: World To End After Two Snowy Days In Salento, Puglia, Southern Italy, Tears On Macedonia Icon
- Eugene Cernan, Hometown Astronaut of Bellwood Illinois dead at 82.
- Anomaly! At 35% Discount For Ten More Days
- Lisa Long Leg: Vongehr’s Rational Free Speech Trump Cross For The Alt Right Revolution Of Love
- "I don't know why my comment's formatting was lost in the transmission, so that it is now one big..."
- "“If you don't use probabilities then how else do you do it? At any rate that's not a criticism..."
- "Tomasso, Congratulations, may you enjoy a long and happy life together with Kalliopi! Best regards..."
- "Found another one : http://www.dailystar.co.uk/news/latest-news/545975/end-of-the-world-Gods-vengeance..."
- "Thanks :). Actually there are so many fake doomsday red top tabloid stories that I tend to wait..."
- If You Think Fentanyl Is Bad...
- Let's Learn a Lesson from Theranos
- Guardians of Truth: Mike Huckabee Lauds Us, We Ruin Things for RFK Jr., And More Media Links
- Massachusetts Becomes the 20th State Where Naturopaths Can Hurt You
- Turmeric- The New Superfood. Oops. Superfad.
- CRRREST Education: How to Fix America's Illiteracy Problem