Synthetic Genomics announceda multi-year research and development agreement with Lung Biotechnology to develop humanized pig organs using synthetic genomic advances. The collaboration will focus upon developing organs for human patients in need of transplantation, with an initial focus on lung diseases.
In the United States alone, about 400,000 people die annually from various forms of lung disease including cancer. 2,000 people are saved with a lung transplant and about the same number are added to the transplant wait list annually. 99% of deaths due to lung failure are unavoidable because of the shortage of transplantable human lungs.
Previous attempts to use animal organs have failed due to genomic incompatibilities, especially with respect to immune and coagulation systems. The collaboration between Synthetic Genomics and Lung Biotechnology aims to eliminate these genomic incompatibilities.
Using DNA design, DNA synthesis and genome editing, as well as genome modification tools,
will develop engineered primary pig cells with modified genomes. This work will entail modification of a substantial number of genes at an unprecedented scale and efficiency. United Therapeutics, parent company of Lung Biotechnology, will leverage its xenotransplantation expertise to implant these engineered cells, generating pig embryos which develop and are born with humanized lungs. The companies are striving to develop these new methods and advances to create organs that are safe and effective for use in humans.
Lung Biotechnology made a $50,000,000 investment in Synthetic Genomics.
"We believe that our proprietary synthetic genomic tools and technologies, coupled with United Therapeutics' knowledge and advances in regenerative medicine technologies and treatment of lung diseases, should enable us to develop humanized pig organs for safe and effective transplant into humans. We believe this is one of the most exciting and important programs ever undertaken in modern medical science," said J. Craig Venter, Ph.D., Founder and CEO, SGI.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Doomsday Dashboard Makes Tracking The Apocalypse Convenient
- When Does Quantum Mechanics Become Classical Physics?
- Updating Fermi's Paradox – The Super Fermi Paradox
- Intellectually Gifted Kids And Learning Disabilities Often Go Hand In Hand
- Dark Matter - Now With More Darkness
- Spring Flukes: New 3-Sigma Signals From LHCb And ATLAS
- Orthorexia Nervosa: The Righteous Health Food Obsession
- "This got me reading the Wikipedia article on Neuropeptide Y.Implicated in so many processes, one..."
- "Still visible! Nice!Cheers,T...."
- "Size is not the criterion for quantum coherence. Some quantum effects, notably superfluidity and..."
- "It's a science-fiction trope that we must be outmatched but we might be first and 4 billion years..."
- "I'm still not completely there, but over the course of time I have started to engage the idea that..."
- Honey bees use different sets of genes, different mechanisms to fight infections
- Genetic mutation may explain why flu can kill
- Why popular antacids may increase chance of bone fractures
- Antibiotic use in livestock expected to increase - what about effectiveness?
- This is your brain in the supermarket