Synthetic Genomics announceda multi-year research and development agreement with Lung Biotechnology to develop humanized pig organs using synthetic genomic advances. The collaboration will focus upon developing organs for human patients in need of transplantation, with an initial focus on lung diseases.
In the United States alone, about 400,000 people die annually from various forms of lung disease including cancer. 2,000 people are saved with a lung transplant and about the same number are added to the transplant wait list annually. 99% of deaths due to lung failure are unavoidable because of the shortage of transplantable human lungs.
Previous attempts to use animal organs have failed due to genomic incompatibilities, especially with respect to immune and coagulation systems. The collaboration between Synthetic Genomics and Lung Biotechnology aims to eliminate these genomic incompatibilities.
Using DNA design, DNA synthesis and genome editing, as well as genome modification tools,
will develop engineered primary pig cells with modified genomes. This work will entail modification of a substantial number of genes at an unprecedented scale and efficiency. United Therapeutics, parent company of Lung Biotechnology, will leverage its xenotransplantation expertise to implant these engineered cells, generating pig embryos which develop and are born with humanized lungs. The companies are striving to develop these new methods and advances to create organs that are safe and effective for use in humans.
Lung Biotechnology made a $50,000,000 investment in Synthetic Genomics.
"We believe that our proprietary synthetic genomic tools and technologies, coupled with United Therapeutics' knowledge and advances in regenerative medicine technologies and treatment of lung diseases, should enable us to develop humanized pig organs for safe and effective transplant into humans. We believe this is one of the most exciting and important programs ever undertaken in modern medical science," said J. Craig Venter, Ph.D., Founder and CEO, SGI.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Great Earthquakes Doubled In The Most Recent 10 Year Period - What That Means
- Why Climate 'Uncertainty' Is No Excuse For Doing Nothing
- What Americans Fear Most Isn't Ebola Or Terrorism, It's...
- Moderate Pot Use By Adolescents Doesn't Hurt IQ
- Cosmic Rays Jeopardize Deep-Space Astronaut Missions
- Slavery In America: Back In The Headlines
- HPV Vaccine Does Not Cause Multiple Sclerosis
- "Nah. It's not free for the iPhone/iPad/iPod Touch. Apple products usually don't play nice with..."
- "http://www.cdc.gov/vaccinesafety/vaccines/HPV/index.html says no interesting difference in side..."
- "Tommaso, I fully agree with you that for the moment it would be unwise and unjustified to committ..."
- "Chaos, thanks, I couldn't come up with the word. Well, sure. The article really didn't work to..."
- "So many decisions seem to be made by ISEBYs — in someone else’s back yard. ..."
- Anti-conventional ag movement spurs Big Ag to look to organic pesticides
- Can people really inherit memories?
- An end to fat shaming? The 50 year DNA mystery of metabolic dysfunction may soon be solved
- Egg freezing: a smart career move?
- Women carry fetal DNA long after children’s birth
- Despite resistance, China will dominate future of GMOs
- UNC scientists discover hidden subpopulation of melanoma cells
- Teenage self-harm linked to problems in later life
- Unsteady on your feet? Little touches could make all the difference
- Promising blood biomarkers identified for colorectal cancer: Is a screening blood test within reach?
- Studies must be carried out to determine whether exercise slows the onset of type 1 diabetes in children and adults