Synthetic Genomics announceda multi-year research and development agreement with Lung Biotechnology to develop humanized pig organs using synthetic genomic advances. The collaboration will focus upon developing organs for human patients in need of transplantation, with an initial focus on lung diseases.
In the United States alone, about 400,000 people die annually from various forms of lung disease including cancer. 2,000 people are saved with a lung transplant and about the same number are added to the transplant wait list annually. 99% of deaths due to lung failure are unavoidable because of the shortage of transplantable human lungs.
Previous attempts to use animal organs have failed due to genomic incompatibilities, especially with respect to immune and coagulation systems. The collaboration between Synthetic Genomics and Lung Biotechnology aims to eliminate these genomic incompatibilities.
Using DNA design, DNA synthesis and genome editing, as well as genome modification tools,
will develop engineered primary pig cells with modified genomes. This work will entail modification of a substantial number of genes at an unprecedented scale and efficiency. United Therapeutics, parent company of Lung Biotechnology, will leverage its xenotransplantation expertise to implant these engineered cells, generating pig embryos which develop and are born with humanized lungs. The companies are striving to develop these new methods and advances to create organs that are safe and effective for use in humans.
Lung Biotechnology made a $50,000,000 investment in Synthetic Genomics.
"We believe that our proprietary synthetic genomic tools and technologies, coupled with United Therapeutics' knowledge and advances in regenerative medicine technologies and treatment of lung diseases, should enable us to develop humanized pig organs for safe and effective transplant into humans. We believe this is one of the most exciting and important programs ever undertaken in modern medical science," said J. Craig Venter, Ph.D., Founder and CEO, SGI.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- A Dimuon Particle At 30 GeV In ALEPH ??
- President Obama, Why Humans On Mars Right Now Are Bad For Science
- EPA Again Delays Report On Safety Of Glyphosate
- IPhone Lab Detects Cancer, May Lead To Instant Diagnosis
- Following Speech In Background Noise - The Problem May Not Be Your Ears
- Nitrate-Reducing Microbes Linked To Migraine Headaches
- Physics Outreach With Music
- "Oh, a colloquial term. Weird, off center, not normal. I.e. it is not normal behaviour. It indicates..."
- "Even a such a numbskull as myself, I thought this from the beginning of the idea. If land is too..."
- "That brings a big smile to my face!..."
- "This sounds very much like the boy-crying-wolf story. If the members of the Aleph experiment have..."
- "they are just closet sadists. So now ur a troll as well then :| Fantastic...."
- Improved 'Screen Time' Guidelines Could Make Parents & Kids Happier
- Dr. Jamie Wells Named One Of America's Top Pediatricians
- Why Did EPA Delay Its Glyphosate Safety Report?
- Scientists Should Fight Postmodern Public Values
- Stupid Health Scare For Hep C Drugs
- Our Lack of Awareness about Food Consumption & Waste