Synthetic Genomics announceda multi-year research and development agreement with Lung Biotechnology to develop humanized pig organs using synthetic genomic advances. The collaboration will focus upon developing organs for human patients in need of transplantation, with an initial focus on lung diseases.
In the United States alone, about 400,000 people die annually from various forms of lung disease including cancer. 2,000 people are saved with a lung transplant and about the same number are added to the transplant wait list annually. 99% of deaths due to lung failure are unavoidable because of the shortage of transplantable human lungs.
Previous attempts to use animal organs have failed due to genomic incompatibilities, especially with respect to immune and coagulation systems. The collaboration between Synthetic Genomics and Lung Biotechnology aims to eliminate these genomic incompatibilities.
Using DNA design, DNA synthesis and genome editing, as well as genome modification tools,
will develop engineered primary pig cells with modified genomes. This work will entail modification of a substantial number of genes at an unprecedented scale and efficiency. United Therapeutics, parent company of Lung Biotechnology, will leverage its xenotransplantation expertise to implant these engineered cells, generating pig embryos which develop and are born with humanized lungs. The companies are striving to develop these new methods and advances to create organs that are safe and effective for use in humans.
Lung Biotechnology made a $50,000,000 investment in Synthetic Genomics.
"We believe that our proprietary synthetic genomic tools and technologies, coupled with United Therapeutics' knowledge and advances in regenerative medicine technologies and treatment of lung diseases, should enable us to develop humanized pig organs for safe and effective transplant into humans. We believe this is one of the most exciting and important programs ever undertaken in modern medical science," said J. Craig Venter, Ph.D., Founder and CEO, SGI.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Nibiru Internet Hoax "Blood Moon" Video - Kudos To Independent For Straight Debunking Article :).
- Your Microbiome Did Not Cause Your Weight Problem
- A Great Blitz Game
- On Sexuality, You Weren't Born That Way, Says Paper
- Your Coffee Habits May Be Written In Your DNA
- Anomaly!: Book News And A Clip
- Beekeeping Fad And The Stress Of Traveling Is Harmful To Bees
- "Yes I agree, it's especially sad when very young children get worried about this stuff, when there's..."
- "LocalFluff - just to say I didn't delete your comment on Stuart's post, or hide it - it was automatically..."
- "Yes I agree. I think there is a lot of hope as well, there are many who are working to save the..."
- "Oh that was just a joke. We have a way of telling jokes in the UK that we use sometimes - a very..."
- "Kaylee, oh sorry to hear that. Yes I know what you mean, from others who are in the same situation..."
- Commonly Cited Stat of 10 Bacteria for Every 1 Human Cell Is Wrong
- Why The EpiPen And Other Generic Drugs Are So Expensive
- Latest IARC Report Connects Fatness with More Cancers
- Fact Checking Mylan Claims They Raised The EpiPen Price Because of Improvements
- I’ve Had More Exposure To Agent Orange Than Anyone: Here’s What I Know
- Brussels – a Final Destination for Medical Care