Commonly used pneumococcal polysaccharide vaccines do not appear to be effective for preventing pneumonia, found a study by a team of researchers from Switzerland and the United Kingdom writing in the Canadian Medical Association Journal.
In many industrialized countries, polysaccharide pneumococcal vaccines (PPVs) are currently recommended to help prevent pneumococcal disease in people aged 65 and over and for younger people with increased risk due to conditions like HIV. Studies have shown conflicting results regarding the efficacy of PPV.
The study, a systematic review and meta-analysis, looked at 22 clinical trials, reviews and meta-analyses and more than 100,000 participants from countries in North America as well as India, Africa, Latin America and the Caribbean. Unlike other similar studies the authors examined the reasons why different clinical trials produced different results. They found that the quality of the studies substantially affected the results. When only high quality trials were included, there was no evidence that PPVs could prevent pneumonia. The study adds to the ongoing debate around effectiveness of the vaccine.
"Policy makers may therefore wish to reconsider their current recommendations for PPV, especially where routine pneumococcal conjugate immunization has been introduced," conclude Dr. Matthias Egger from the University of Bern, Switzerland and coauthors.
However, in a related commentary, Dr. Ross Andrews and coauthor from the Menzies School of Health Research, Darwin, Australia state that the researchers' conclusions exceed the evidence presented. They caution that there should be no change in vaccine policy in countries that recommend PPV to prevent invasive pneumococcal disease.
Anke Huss, Pippa Scott, Andreas E. Stuck , Caroline Trotter, Matthias Egger, 'Efficacy of pneumococcal vaccination in adults:a meta-analysis', CMAJ JANUARY 6, 2009 180(1)
Ross Andrews, Sarah A. Moberley, 'The controversy over the efficacy of pneumococcal vaccine', CMAJ JANUARY 6, 2009 180(1)
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- #GAMERGATE Style Harassment Does Not Happen in the Male Dominated Sciences
- Climate Change: It’s Only Human To Exaggerate, But Science Itself Does Not
- From Mindless Physics To Physics Of Mind
- Should First Responders Use Acupuncture And Hypnosis During Disasters?
- 24 hours with Windows 10 on a Surface Pro 3
- How Mitochondria Began - Parasitic Coevolution Gets A New Wrinkle
- Not All Fat Is Equal: Amping Up Adenosine May Melt 'Love Handles'
- "This kind of nonsense is what I am not a fan of - unfortunately, because hypnosis works so infrequently..."
- "It's because scientists don't completely cram their lectures full of politics, blacklist people..."
- "Hank I found this link on Facebook and I see on your about me page you have written a book well..."
- "No correlation? 8 of the 10 wealthiest counties voted for the president in 2008 and 2012. And they..."
- "You think this bothers me? Both gamergate and anti-gamergate supporters are behaving in immature..."
- Natural Resources Defense Council sues EPA to block rollout of Dow Enlist Duo GMO system
- Enviros file suit to block new Dow AgroSciences GMO herbicide and seeds
- Couples can protect children from devastating mutations with new IVF methods
- Food 2.0: Will farmers be able to meet the ecological challenges ahead?
- General Mills’ Cascadian Farm launches ‘bee-friendly’ campaign, GMO critics unimpressed
- Can genes pass from genetically modified food into our blood, posing dangers?
- Study shows medication is frequently, unintentionally given incorrectly to young children
- Mummy remains refute antiquity of ankylosing spondylitis
- Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025
- Head injury causes the immune system to attack the brain
- Viagra protects the heart beyond the bedroom