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    UCLH Study Demonstrates Rapid Patient Screening Could Cut MRSA Rates By Almost 40 Per Cent
    By Anna Ohlden | December 18th 2007 02:30 AM | Print | E-mail | Track Comments

    OXFORD, England, December 18 /PRNewswire/ --

    BD Diagnostics, a segment of BD (Becton, Dickinson and Company), today announced that a major study published in the British Journal of Surgery demonstrates that rapid screening for meticillin-resistant Staphylococcus aureus (MRSA) could help reduce hospital infection rates by almost 40 per cent. Led by researchers at the University College London Hospital NHS Foundation Trust (UCLH), the study investigated whether using a two-hour rapid screening test to identify MRSA carriers could effect a significant reduction in infection rates. The researchers who conducted the trial of approximately 19,000 surgical patients at University College Hospital concluded that use of the rapid molecular test is cost-effective and reduces MRSA infection rates.

    "MRSA has a devastating impact on patients and their families," said Peter Wilson, Consultant Microbiologist, UCLH, who led the research study. "To win the war on MRSA, hospitals need to consider effective new technologies, such as rapid tests which can help speed the selection of appropriate interventions. It is important to identify methods which can be demonstrated to be effective in reducing hospital infection rates. Our research shows rapid molecular screening to identify carriers prior to elective or emergency surgery is an important tool toward that goal."

    The authors tested 18,810 surgery patients admitted to the hospital between January and December 2006 with the BD GeneOhm(TM) MRSA Assay, a rapid, two-hour molecular test for the detection of MRSA from nasal specimens. The rapid test revealed that 4.5 per cent of screened patients were carrying MRSA when they were admitted to the hospital. Patients who tested positive as carriers of MRSA were treated with a topical suppression in order to reduce the risk of infection and potential transmission to others. The overall rate of MRSA bloodstream infections fell by 38.6 per cent compared with 2005 rates. When compared with the mean of the preceding six years, the rate fell by 38.5 per cent.

    The annual cost for the active screening programme at UCLH was 302,500 pounds Sterling. Cost savings were measured in terms of sending a patient home earlier as an infection was avoided. Using the 2005 MRSA infection rates, the cost savings in 2006 were 545,400 pounds, translating to a net savings of 242,900 pounds for the year.

    Based upon the success of the active screening study, UCLH plans to expand its screening programme to include medical (non-pre-surgical) patients. The rapid screening programme is just one avenue UCLH has pursued to reduce its MRSA rates. Prior to the screening study, the Trust had already introduced intensive hand hygiene campaigns and improved infection control around intravenous line procedures. UCLH recently became the first institution in the country to introduce "infection-resistant" keyboards.

    There is a 23 per cent mortality rate among patients with MRSA bacteraemia (bacterial infections of the bloodstream). In the early 1990s, 2 per cent of Staphylococcus aureus bacteraemias were due to MRSA in the UK; the mean figure is now about 45 per cent and UK rates of MRSA bloodstream infections are among the highest in Europe. The UK government has set a target that by 2008 all hospitals must reduce infection rates by 50 per cent in comparison to 2003-2004 base rates. However, recent official figures from the Health Protection Agency showed that there has only been a reduction of 20 per cent across all UK hospitals.

    The Health Act 2006: Code of practice for the prevention and control of healthcare-associated infections, published by the Department of Health (DOH), states that hospitals should make provisions for pre-admission MRSA screening in addition to decontamination and isolation of colonised patients. While the DOH does not specify the type of screening that should be used, it does suggest decolonisation of emergency orthopaedic patients and all critical care patients should begin immediately upon admission, unless a rapid screening method is used, owing to the fact that the results for culture-screening will not be known until after the critical period for these patients.

    About the BD GeneOhm MRSA Assay

    The BD GeneOhm MRSA assay is performed on a nasal swab specimen with a real-time polymerase chain reaction instrument that rapidly identifies patients who are carriers of MRSA. It was used in the study because it provides results in two hours, thereby enabling UCLH to swiftly implement appropriate interventions. In contrast, traditional culture screening methods can take up to 72 hours. UCLH was the first NHS Trust to introduce this rapid molecular technique for routine screening. The rapid test is quicker and easier to read because it is based on the presence of MRSA-specific DNA. Traditional methods take longer because they rely on growing bacteria and subsequent testing for antibiotic resistance on culture plates.

    About BD

    BD, a leading global medical technology company that manufactures and sells medical devices, instrument systems and reagents, is dedicated to improving people's health throughout the world. BD is focused on improving drug therapy, enhancing the quality and speed of diagnosing infectious diseases, and advancing research and discovery of new drugs and vaccines. The Company's capabilities are instrumental in combating many of the world's most pressing diseases. Founded in 1897 and headquartered in Franklin Lakes, New Jersey, BD employs approximately 28,000 people in approximately 50 countries throughout the world. The Company serves healthcare institutions, life science researchers, clinical laboratories, industry and the general public. For more information, please visit www.bd.com.

    Journalists may also visit www.bd.com/press/newsroom/hais.asp for more information.

    Web site: http://www.bd.com http://www.bd.com/press/newsroom/hais.asp

    Ian Lloyd of UCLH, +44-020-7380-9506, Ian.Lloyd@uclh.nsh.uk; Barbara Kalavik of BD, +1-201-847-4209, Barbara_Kalavik@bd.com; or Wendy Gerber of Manning, Selvage and Lee, +44-020-7878-3259, Wendy.Gerber@mslpr.co.uk, all for BD