Indian arid zone occupies an area of about 0.3 million sq. km.  90 percent of which about 2,70,000 sq. km. is confined to north west Indian covering most of Western Rajasthan, part of Gujarat and small portions of Punjab and Haryana.  India has over 180 million of wasteland out of which 90 million ha is uncultivable. The degraded and denuded lands arise due to soil erosions as well as secondary salinizations. However Calotropis procera is a potential plant for bioenergy and biofuel production in semi arid regions of the country because it is able to grow on such lands. The plant has a growth potential of 2 dry tones to 40 dry tones per ha depending on the agro climatic conditions of it’s growth. The plant has high level of regeneration potential and could be harvested up to 4 times a year. The plant yields valuable hydrocarbons which could be converted into diesel substitutes. The bio-diesel derived from Calotropis procera is free from NOx gases, S02 and Suspended Particulate Matter (SPM) and has high cetane value. Due to it’s enormous potential for growth under adverse climatic conditions Calotropis procera is suggested as potential plant for bio-diesel production under semi-arid and arid conditions.