Researchers have identified a gene which can be used to predict how susceptible a young person is to the mind-altering effects of smoking marijuana, an increasing concern as the cultural movement shifts toward legalization. Around one percent of cannabis users develop psychosis. It is known that smoking cannabis daily doubles an individual's risk of developing a psychotic disorder, but it has been difficult to establish who is most vulnerable.
Previous research has found a link between the AKT1 gene and people who have gone on to develop psychosis. In the new study, Celia Morgan, Professor of Psychopharmacology at the University of Exeter and Professor Val Curran and her team at University College London found that young people with variation in the 'AKT1' gene experienced visual distortions, paranoia and other psychotic-like symptoms more strongly when they were under the influence of cannabis.
Researchers have previously found a high prevalence of one variant of the AKT1 genotype in cannabis users who went on to develop psychosis as a result of their use. This is the first research that shows the link between the same gene and the effects of smoked cannabis in healthy young people. The study involved 442 young cannabis users who were tested while under the influence of the drug, and while sober. The researchers measured the extent of the symptoms of intoxication and effect on memory loss and compared it to results seven days later when the young people were drug free. They found that those who with this variation in the AKT1 geneotpye were more likely to experience a psychotic response.
As part of the study, researchers gained permission from the Home Office to analyse the cannabis samples for their make-up and strength. Samples were dropped off at a police station and analyzed by the forensic science service.
Professor Morgan said, "These findings are the first to demonstrate that people with this AKT1 genotype are far more likely to experience strong effects from smoking cannabis, even if they are otherwise healthy. To find that having this gene variant means that you are more prone to mind-altering affects of cannabis when you don't have psychosis gives us a clue as to how it increases risk in healthy people. Putting yourself repeatedly in a psychotic or paranoid state might be one reason why these people could go on to develop psychosis when they might not have done otherwise."
"Animal studies have found that males have more of the receptors that cannabis works on in parts of the brain important in short term memory, such as the prefrontal cortex. We need further research in this area, but our findings indicate that men could be less sensitive to the memory impairing effects of cannabis than females," added Professor Morgan.
Source: University of Exeter