People with heart health in middle age may live up to 14 years longer, free of cardiovascular disease, compared to peers who have two or more cardiovascular disease risk factors, according to a new paper.

For the analysis, researchers pulled data from five different cohorts included in the Cardiovascular Lifetime Risk Pooling Project and looked at the participants' risk of all forms of fatal and nonfatal cardiovascular disease from ages 45, 55 and 65 through 95 years of age.

All participants were free of cardiovascular disease upon entry into the project and data on the following risk factors was collected: blood pressure, total cholesterol, diabetes and smoking status. The primary outcome measure for the study was any  cardiovascular disease event (including fatal and nonfatal coronary heart disease, all forms of stroke, congestive heart failure, and other cardiovascular disease deaths).

Key results were:

• Individuals with optimal risk factor profiles lived up to 14 years longer free of total CVD than individuals with at least two risk factors.
• Men in middle age had lifetime risks of approximately 60 percent for developing cardiovascular disease.
• Women in middle age had lifetime risks of approximately 56 percent for developing cardiovascular disease.
• Lifetime risks for cardiovascular disease were strongly associated with risk factor burden in middle age.

"We found that many people develop cardiovascular disease as they live into old age, but those with optimal risk factor levels live disease-free longer," said John T. Wilkins, M.D., first author of the study and assistant professor in medicine, cardiology and preventive medicine at  Northwestern University. "We need to do everything we can to maintain optimal risk factors so that we reduce the chances of developing cardiovascular disease and increase the chances that we'll live longer and healthier."  

Published in the Journal of the American Medical Association (JAMA).