Synthetic cathinones which produce effects similar to amphetamines and have been associated with numerous fatalities are derived from cathinone, which is present in the khat plant.

Only supplement makers and buyers think if it happens in nature it must be okay, but the U.S.  Drug Enforcement Administration (DEA)  has a hard time keeping up. They can only ban specific  synthetic cathinones, and did in 2011, but change a molecule and new designer drugs continue to appear, and they aren't banned because they are different.

Many forensic laboratories routinely use gas chromatography/mass spectrometry (GC/MS) to detect the use of drugs in biological samples in fatalities, intoxication or impaired driving cases. However, some of these drugs may actually degrade during the process. Alternative techniques such as liquid chromatography-tandem mass spectrometry (LC/MS/MS) or liquid chromatography-quadrupole-time-of-flight/mass spectrometry (LC-q-TOF) are significantly more expensive and not all laboratories have this capability due to limited resources.


Dr. Sarah Kerrigan is the Chair of the Department of Forensic Science at Sam Houston State University. Credit: Harriet McHale/SHSU

Bath salts were traditionally sold in smoke shops and on the Internet until 2011, when the DEA began banning cathinones, but manufacturers were quick to replace them with slight alternatives to circumvent current legislation. Because of these changes and continued sales on the Internet, it is difficult to regulate, legislate and enforce the laws. In addition, many toxicology labs do not test for these drugs. While identifying these substances in seized drug materials such as pills and powders is relatively easy, it is much harder to detect them in biological evidence. Identification is hampered by drug instability and the possibility of thermal degradation during analysis. 

Among the compounds studied were 4-EMC, 4-MEC, buphedrone, butylone, ethcathinone, ethylone, flephendrone, MDPBP, MMDPV, mephedrone, methcathinone, methedrone, methylone, MPBP, naphyrone, pentedrone, pentylone, PVP and pyrovalerone.

Due to the speed at which these drugs have evolved, a new study calls for a systematic approach to understand how the various structural facets of the synthetic cathinones influence their stability. This approach is believed to be more likely to lend itself to meaningful interpretation of newer analogs and derivatives that have not yet been developed or are still emerging as new designer drugs.

The report, "Improved Detection of Synthetic Cathinones in Forensic Toxicology Samples: Thermal Degradation and Analytical Considerations," is available from the National Criminal Justice Reference Service at and was recently published in the Journal of Analytical Toxicology.

source: Sam Houston State University