LEUVEN, Belgium, LUND, Sweden and BASEL, Switzerland, June 18 /PRNewswire/ -- ThromboGenics NV (Euronext Brussels: THR) and BioInvent International AB (Nordic Exchange: BINV) announce that they have entered into a license agreement with Roche (SWX: ROG) for their jointly developed anti-cancer agent TB-403. TB-403 is a novel monoclonal antibody which blocks Placental Growth Factor (PIGF), one of the growth factors responsible for the development of new blood vessels.

Under the terms of the agreement effective from June 17, 2008 (or if a U.S. anti-trust clearance is required, from the date of receipt of such clearance), Roche will pay ThromboGenics and BioInvent an upfront payment of EUR50 million. In addition, ThromboGenics and BioInvent could potentially receive up to EUR450 million over the term of the collaboration based on the successful completion of a series of development and commercial milestones for multiple indications, as well as double digit royalties on potential product sales, including any backup antibodies based on inhibition of PlGF. ThromboGenics, which discovered TB-403, will receive 60% and BioInvent 40% of the revenue from the deal. Roche will have a worldwide, exclusive license to develop and commercialize TB-403. ThromboGenics and BioInvent will retain co-promotion rights for the product in the Benelux, Baltic and Nordic regions.

ThromboGenics and BioInvent are responsible for any remaining costs associated with the recently completed Phase Ia trial in healthy volunteers. Roche will assume responsibility for all future development costs for this novel therapy, including the costs of the pending Phase Ib trial in patients to be run by ThromboGenics and BioInvent. ThromboGenics and BioInvent in conjunction with Roche will form a Joint Steering Committee to oversee research and development activities. In addition, Roche will also provide funding to ThromboGenics and BioInvent for research on non-cancer indications and supply of clinical material until transfer of manufacturing.

TB-403 (Anti-PIGF) has completed an initial Phase I clinical trial and recently received approval to enter a Phase Ib dose escalation trial. This Phase Ib trial will be conducted in patients with advanced cancer and is due to commence shortly in Denmark.

TB-403 has the potential to be a major advance in the treatment of cancer. It is a humanized monoclonal antibody that blocks the formation of the new blood vessels that are needed by solid tumours to support their growth. TB-403 has the potential to minimize both the growth and spread of cancer cells.

Professor Désiré Collen, CEO and Chairman of ThromboGenics, said: "TB-403 has generated a great deal of interest from the pharmaceutical community. Therefore, we are delighted that we have signed this major licensing agreement with Roche, given their expertise and success in bringing novel anti-cancer agents to the market. This deal represents a significant milestone in ThromboGenics' development as a company. It also reflects TB-403's potential as a promising treatment for cancer, and is a testament to the hard work and high quality science on which ThromboGenics' business is based. The funding from this deal also gives us the financial resources to continue to build our strong pipeline. We look forward to working with Roche, and to the successful development of this unique anti-cancer agent."

Svein Mathisen, CEO of BioInvent, commented on the deal: "We believe that TB-403 has great potential for the treatment of cancer, with its unique mode of action targeting PlGF, and are delighted that Roche has recognised this potential. This agreement demonstrates our ability to identify innovative projects and to realize the clinical potential of a therapeutic antibody. We look forward to seeing the product progress further through clinical development and towards market."

Dan Zabrowski, Global Head of Pharma Partnering, Roche added; "We are very pleased to enter this partnership with ThromboGenics and BioInvent. This novel antibody, TB-403 has the potential to play a major role in the treatment of cancer and we are committed to driving ahead with its development. In addition, we look forward to developing a strong working relationship with ThromboGenics and BioInvent."

Notes to Editors:

About TB-403

TB-403 was in-licensed by ThromboGenics from the Flanders Institute for Biotechnology (VIB) at the University of Leuven, Belgium, where the therapeutic potential of anti-PlGF agents to treat cancer was first developed in the laboratory of Prof. Peter Carmeliet.

Angiogenesis inhibitors such as TB-403 are therapeutic agents that work by blocking the development of new blood vessels, thereby depriving growing cancer tumour cells of oxygen and nutrients. This approach in turn is thought to stop the tumour from growing and spreading to other parts of the body. PlGF is a homologue of VEGF and current preclinical evidence suggests that it may not affect normal, physiological angiogenesis and is predominantly involved in angiogenesis of malignant tissue.

About ThromboGenics

ThromboGenics is a biotechnology company focused on discovery and development of biopharmaceuticals for the treatment of a range of vascular diseases. The Company has several programs in Phase II clinical development including microplasmin, which is being evaluated as a treatment for vitreoretinal disorders and as a thrombolytic agent for vascular occlusive diseases, including acute stroke. ThromboGenics is also developing novel antibody therapeutics in collaboration with BioInvent International; these include TB-402 (Anti-Factor VIII), scheduled to enter Phase II clinical development in 2008, and TB-403 (Anti-PlGF). ThromboGenics and BioInvent have recently signed a license agreement with Roche for TB-403 worth EUR 500 million plus royalties. TB-403 is scheduled to enter a Phase Ib clinical trial in mid-2008 for the treatment of cancer.

ThromboGenics has built strong links with the University of Leuven and the Flanders Institute for Biotechnology (VIB) and has exclusive rights to certain therapeutics developed at these institutions. ThromboGenics is headquartered in Leuven, Belgium and has subsidiaries in Dublin, Ireland and New York, U.S. The Company is listed on Eurolist by Euronext Brussels under the symbol THR. More information is available at http://www.thrombogenics.com.

About BioInvent

BioInvent International AB, listed on The Nordic Exchange (OMXS:BINV), is a research-based pharmaceutical company that focuses on developing antibody drugs. The Company is currently running innovative drug projects within the areas of thrombosis, cancer, atherosclerosis and ophthalmic diseases. In January 2007 the Company announced a major strategic alliance with American-based Genentech, Inc. in the cardiovascular field. These projects are based on a competitive and in substance patented technology platform. The scope and strength of this platform is also utilised by partners, such as ALK-Abelló, ImmunoGen, OrbusNeich, Sanofi-Aventis, UCB and XOMA.

About Roche

Headquartered in Basel, Switzerland, Roche is one of the world's leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As the world's biggest biotech company and an innovator of products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people's health and quality of life. Roche is the world leader in in-vitro diagnostics and drugs for cancer and transplantation, and is a market leader in virology. It is also active in other major therapeutic areas such as autoimmune diseases, inflammatory and metabolic disorders and diseases of the central nervous system. In 2007 sales by the Pharmaceuticals Division totalled 36.8 billion Swiss francs, and the Diagnostics Division posted sales of 9.3 billion francs. Roche has R&D agreements and strategic alliances with numerous partners, including majority ownership interests in Genentech and Chugai, and invested over 8 billion Swiss francs in R&D in 2007. Worldwide, the group employs about 79,000 people. Additional information is available on the Internet at http://www.roche.com.

For further information, please contact: ThromboGenics: Prof. Désiré Collen, CEO Tel: +32(0)16-34-61-94 Patrik De Haes, COO Tel : +32(0)16-34-61-94 patrik.dehaes@thrombogenics.com Stuart Laermer, Chief Business Officer Tel: +1-212-201-0920 stuart.laermer@thrombogenics.com BioInvent: Svein Mathisen, President & CEO Tel: +46(0)46-286-85-67 Mob: +46(0)708-97-82-13 svein.mathisen@bioinvent.com Cristina Glad, Executive Vice President Tel: +46(0)46-286-85-51 Mob: +46(0)708-16-85-70 cristina.glad@bioinvent.com Roche: Peter Sandbach Roche Pharma Partnering +41-61-688-3408 peter.sandbach@roche.com Dave Andrews Roche Pharma Partnering +41-61-687-056 david.andrews@roche.com Citigate Dewe Rogerson: Amber Bielecka, Sylvie Berrebi, David Dible Tel: +44(0)20-7282-1050 amber.bielecka@citigatedr.co.uk College Hill Adam Michael, Tony Stephenson, John McIntyre Tel: +44(0)20-7866-7900 bioinvent@collegehill.com ThromboGenics NV Campus Gasthuisberg Herestraat 49 B-3000 Leuven Belgium Tel: +32(0)16-34-61-94 http://www.thrombogenics.com BioInvent International AB (publ) Co. reg. No. 556537-7263, Address: Sölvegatan 41 Mailing address: SE-223 70 LUND Tel: +46(0)46-286-85-50 info@bioinvent.com http://www.bioinvent.com

For further information, please contact: ThromboGenics:, Prof. Désiré Collen, CEO, Tel: +32(0)16-34-61-94; Patrik De Haes, COO, Tel: +32(0)16-34-61-94, patrik.dehaes@thrombogenics.com; Stuart Laermer, Chief Business Officer, Tel: +1-212-201-0920, stuart.laermer@thrombogenics.com; BioInvent:, Svein Mathisen, President & CEO, Tel: +46(0)46-286-85-67, Mob: +46(0)708-97-82-13, svein.mathisen@bioinvent.com; Cristina Glad, Executive Vice President, Tel: +46(0)46-286-85-51, Mob: +46(0)708-16-85-70, cristina.glad@bioinvent.com; Roche:, Peter Sandbach, Roche Pharma Partnering, +41-61-688-3408, peter.sandbach@roche.com; Dave Andrews, Roche Pharma Partnering, +41-61-687-056, david.andrews@roche.com; Citigate Dewe Rogerson:, Amber Bielecka, Sylvie Berrebi, David Dible, Tel: +44(0)20-7282-1050, amber.bielecka@citigatedr.co.uk; College Hill, Adam Michael, Tony Stephenson, John McIntyre, Tel: +44(0)20-7866, bioinvent@collegehill.com; ThromboGenics NV, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium, Tel: +32(0)16-34-61-94, http://www.thrombogenics.com; BioInvent International AB (publ), Co. reg. No. 556537-7263,, Address: Sölvegatan 41, Mailing address: SE-223 70 LUND, Tel: +46(0)46-286-85-50, info@bioinvent.com, http://www.bioinvent.com