America’s next biology top model hails from Antarctica. Thiomicrospira arctica, the bacteria from an isolated ecosystem in under the Taylor glacier, was big news last week for both biologists, geologists and perhaps even astrobiologists. This extremophile’s unique quirks gave us a rush of information about its evolution and surrounding geography simply because its history has been relatively simple.
Without influence from predators, pollution, and zoological diversity, we can be pretty darn sure that changes in its harsh antarctic environment caused it to become the bacteria it is today.

And both populations are sequestered from the muddling diversity of an open culture (no pun intended). Though we can’t put people in a petri dish to create control groups, the Old Order Amish lifestyle has provided us with an excellent substitute. This year alone, Amish genetics were used to shed light on studies of the circadian genes in bipolar patients, hemophilia, hypertension-related genes.

Multiple cases of the same deformities in family members, however, points to a genetic cause. When six victims were found among close relatives in an Old Order Amish community, it raised a red flag for doctors. The traits, in total, were caused by a single mutation in an intestinal kinase that has huge implications in the skeletal and endocrine system formation. This newly discovered syndrome is now known as endocrine cerebro-osteodysplasia, and the consanguinity of the Amish amplified its occurrence and made its genetic cause easy to find.
This is why isolated microecosystems, such as T. arctica’s icy domain, the Galapagos islands, and Lancaster County, Pennsylvania are a gift to researchers. Tiny, isolated populations show us how a group of organisms interact and change, without many of the confounding influences found in a diverse, uncontrollable ecosystem.
In effect, a closed ecosystem like Antarctica’s buried ice lakes or the Galapagos archipelago increase the signal-to-noise ratio for observers; against a simplified background, stories stand out.
"A Multiplex Human Syndrome Implicates a Key Role for Intestinal Cell Kinase in Development of Central Nervous, Skeletal, and Endocrine Systems." Lahiry, Piya et al. American Journal of Human Genetics. 84: 2 134-147, 2009
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