The investigational anti-cancer agent rociletinib (CO-1686) has received the new FDA 'Breakthrough Status' designation, developed to accelerate the approval process for very promising new medical treatments.

For a new study, patients were initially given free base and later hydrogen bromide salt formulations of the drug rociletinib in ongoing 21-day cycles. The hydrogen bromide salt produced better absorption and higher drug exposure in patients and was adopted as the sole form moving forward. The New England Journal of Medicine reports results of a phase I/II study of rociletinib in patients with EGFR-mutant non-small cell lung cancer (NSCLC) that had progressed after previous treatment with EGFR inhibitors.

If you want to know the secrets of healthier eating, think of the kitchen fruit bowl. A fruit bowl makes fruit more convenient, attractive, and normal to eat than if the same fruit were in the bottom of the refrigerator.

A new Cornell study analyzed 112 studies that collected information about healthy eating behaviors and found that most healthy eaters did so because a restaurant, grocery store, school cafeteria, or spouse made foods like fruits and vegetables visible and easy to reach (convenient), enticingly displayed (attractive), and appear like an obvious choice (normal). "A healthy diet can be as easy as making the healthiest choice the most convenient, attractive, and normal," said Brian Wansink, Ph.D., Director of the Cornell Food and Brand Lab.

If you're finding it difficult to stick to a diet, a new paper says you can likely blame hunger-sensitive cells in your brain known as AGRP neurons. According to new experiments, these neurons are responsible for the unpleasant feelings of hunger that make snacking irresistible. 

Cystic fibrosis is an inherited, life-threatening disorder that damages the lungs and digestive system. It is most commonly caused by a mutation in the cystic fibrosis gene known as F508del. The disorder has no cure, and treatment typically consists of symptom management. Previous attempts to treat the disease through gene therapy have been unsuccessful.

A survey of nearly 7,000 people found that 98 percent want to to know if their genetic data contains indicators of a serious preventable or treatable disease. The study comes after the Government's announcement that Genomics England will sequence 100,000 genomes by 2017, begins an important and on-going conversation about how our genomic data is used. 

By 2030, life expectancy in England and Wales is expected to reach 85.7 years for men and 87.6 years for women, losing the gap between male and female life expectancy from 6 years in 1981 to just 1·9 years by 2030, according to a new study. 

Between 1981 and 2012, national life expectancy in England and Wales increased by 8·2 years in men (to 79·5 years) and 6·0 years in women (to 83·3 years). However, national progress has come at the cost of rising inequalities, and the gap between the top and bottom 1% of life expectancies in local authority districts of England and Wales has increased by around 0·9 of a year for men (from 5·2 to 6·1 years) and 1·1 years for women (from 4·5 to 5·6 years).

For not being a planet, Pluto certainly has some intriguing features of one.  NASA’s New Horizons spacecraft has sent back images of bright and dark regions on the surface of faraway Pluto as it gets closer to flyby in mid-July. 

The images were captured using its telescopic Long Range Reconnaissance Imager (LORRI) camera in early to mid-April, as it closed within 70 million miles. A technique called image deconvolution sharpens the raw, unprocessed images beamed back to Earth. New Horizons scientists interpreted the data to reveal the dwarf planet has broad surface markings – some bright, some dark – including a bright area at one pole that may be a polar cap.

Rates of infection with the deadly superbug Clostridium difficile were highest in the Northeast region of the country and in the spring season over the last 10 years, according to a new study.

Researchers from the University of Texas retrospectively analyzed 2.3 million cases of Clostridium difficile infection (CDI) from 2001-2010 and found the highest incidence in the Northeast (8.0 CDI discharges/1000 total discharges), followed by the Midwest (6.4/1000), South (5.0/1000), and the West (4.8/1000).

Seasonally, spring had the most cases (6.2 CDI discharges/1000 total discharges), followed by winter (5.9/1000), summer (5.9/1000) and fall (5.6/1000). Adults and older adults followed overall trends, whereas pediatric CDI was highest in winter.

When we think of genetically modified organisms, we usually picture the modern legal definition and a controversy related to how science can aid in herbicide tolerance and insect resistance, but there are other applications of such engineered plants, such as the incorporation of genes for specific nutrients.  Golden Rice is a famous example. Though it is protested by environmental groups, it has been shown to be able to help prevent blindness and death for millions of children.

A new paper suggests that similar bio-fortification of rice with a gene to produce more folate (vitamin B9) could significantly reduce the risk of spina bifida and other neural tube defect conditions caused by deficiency of this nutrient.

Neuroscientists have discovered brain circuitry for encoding positive and negative learned associations in mice. After finding that two circuits showed opposite activity following fear and reward learning, the researchers proved that this divergent activity causes either avoidance or reward-driven behaviors.