A lone Sentinel cell monitors and coordinates the defense of the entrance to the colon's most sensitive parts. The Sentinel cell detects nearby bacteria and signals to a line of defensive cells to send out a cascade of mucus to push away the invaders. As a final self-sacrificing action the cell commits suicide and ejects itself into the intestinal lumen.
Researchers at the Sahlgrenska Academy, University of Gothenburg, have discovered a new group of cells that can wash away the bacteria that have penetrated through the protective mucus barrier. The discovery, published in the journal Science, may be important in understanding how inflammatory bowel disease, e.g. ulcerative colitis, occurs.