Resveratrol is a naturally occurring polyphenolic phytochemical produced in several plants, especially grapes skin and seeds. One epidemiological study reported a positive association between moderate red wine consumption and a low incidence of cardiovascular disease, known as the "French Paradox." The neuroprotective effects of resveratrol for the treatment of Alzheimer's disease (AD) have been investigated in various in vitro and in vivo models of AD. Despite the high bioactivity of resveratrol in AD, there is poor bioavailability of resveratrol, that is, the concentrations required producing favourable biological effects in the brain and neuronal cells are insufficient to demonstrate efficacy in humans.

Drug treatments for breast cancer patients might soon be designed based on the unique genetic autograph of their tumor.

Certain oncogenes drive solid tumor growth in some breast cancer patients but are just passenger genes in others--expressed but not essential for growth. As a result, tumors in different breast cancer patients may respond differently to the same treatment depending on which oncogenes are active and which are just along for the ride. Identifying the panel of active genes in a patient's tumor--called the functional oncogene signature--could help an oncologist select therapies that target its growth, according to Stephen P. Ethier, Ph.D., Interim Director of the Center for Genomic Medicine at MUSC and senior author on the study.

Racial discrimination, whether it's derogatory language or unequal treatment, impacts communities and individuals in different ways. For children, the effects are sometimes emotional scars, and as a University of Houston researcher discovered, even thoughts of death.

UH psychology professor Rheeda Walker was the lead researcher on the study "A Longitudinal Study of Racial Discrimination and Risk for Death Ideation in African-American Youth." It soon will be published in the journal Suicide and Life-Threatening Behavior and can be viewed online.

Toxic arsenic initially accumulates in the nuclei of plants' cells. This has been revealed by an X-ray examination of the aquatic plant rigid hornwort (Ceratophyllum demersum) using DESY's X-ray source PETRA III. Even at comparatively low concentrations, the arsenic also floods the vacuole, a liquid-filled cavity which takes up most of the cell. Researchers surrounding Hendrik Küpper of the Czech Academy of Sciences, who is a professor at the University of South Bohemia in Ceske Budejovice (Czech Republic), have made this discovery in the course of a project that was set up in Küpper's group by Seema Mishra (now at the National Botanical Research Institute in Lucknow, India). The scientists report their findings in the Journal of Experimental Botany.

As more coal-fired power plants are retired, industry workers are left without many options. There is a light at the end of the tunnel, though.

In a new study published in Energy Economics, researchers from Michigan Technological University and Oregon State University offer hope for coal workers for high-quality employment in the rapidly expanding solar photovoltaic industry.

Joshua Pearce, who holds a dual appointment in materials science and engineering as well as electrical and computer engineering at Michigan Tech, helped assess what it would take to retrain workers for a different energy field.

Researchers from North Carolina State University have developed a new tool for detecting and measuring the polarization of light based on a single spatial sampling of the light, rather than the multiple samples required by previous technologies. The new device makes use of the unique properties of organic polymers, rather than traditional silicon, for polarization detection and measurement.

Light consists of an electric field. That electric field oscillates, and the direction in which that field oscillates is the light's polarization. If the field oscillates randomly, it's referred to as unpolarized light. The polarization of light can be affected in predictable ways when light bounces off, or is scattered by, physical objects.

Physicians have been mystified by chronic fatigue syndrome, a condition where normal exertion leads to debilitating fatigue that isn't alleviated by rest. There are no known triggers, and diagnosis requires lengthy tests administered by an expert.

Now, for the first time, Cornell University researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.

In a study published June 23 in the journal Microbiome, the team describes how they correctly diagnosed myalgic encephalomyeletis/chronic fatigue syndrome (ME/CFS) in 83 percent of patients through stool samples and blood work, offering a noninvasive diagnosis and a step toward understanding the cause of the disease.

PRINCETON, N.J.--A new laser-based uranium enrichment technology may provide a hard-to-detect pathway to nuclear weapons production, according to a forthcoming paper in the journal Science & Global Security by Ryan Snyder, a physicist with Princeton University's Program on Science and Global Security.

One example of this new third-generation laser enrichment technique may be the separation of isotopes by laser excitation (SILEX) process which was originally developed in Australia and licensed in 2012 for commercial-scale deployment in the United States to the Global Laser Enrichment consortium led by General Electric-Hitachi. Research on the relevant laser systems is also currently ongoing in Russia, India and China.

Researchers, led by Carnegie Mellon University President Subra Suresh and MIT Principal Research Scientist Ming Dao, have created a new computer model that shows how tiny slits in the spleen prevent old, diseased or misshapen red blood cells from re-entering the bloodstream. Members of this multidisciplinary team include specialists in mathematics, supercomputing, clinical medicine, engineering and computational biology.

Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Dental and Craniofacial Research (NIDCR), and the National Heart, Lung and Blood Institute (NHLBI), all parts of the National Institutes of Health (NIH), describe how combining engineered anthrax toxin proteins and existing chemotherapy drugs could potentially yield a therapy to reduce or eliminate cancerous tumors. The findings, based on testing in mice, will appear this week in the Early Edition of the Proceedings of the National Academy of Sciences.