The chemical marks littering the DNA inside our cells have been like trees in front of us - important, but we couldn't see the whole forest so we could study one gene at a time.
New high-throughput DNA sequencing technology has enabled researchers at the Salk Institute for Biological Studies to map the precise position of individual DNA modifications throughout the genome of the plant Arabidopsis thaliana, and chart its effect on the activity of any of Arabidopsis’ roughly 26,000 genes.
The Salk study, which appears today in Cell, paints a detailed picture of a dynamic and ever-changing, yet highly controlled, epigenome, the layer of genetic control beyond the regulation inherent in the sequence of the genes themselves.