Scientists at the University of Cambridge have successfully created 'mini-lungs' using stem cells derived from skin cells of patients with cystic fibrosis, and have shown that these can be used to test potential new drugs for this debilitating lung disease.

The research is one of a number of studies that have used stem cells - the body's master cells - to grow 'organoids', 3D clusters of cells that mimic the behaviour and function of specific organs within the body. Other recent examples have been 'mini-brains' to study Alzheimer's disease and 'mini-livers' to model liver disease. Scientists use the technique to model how diseases occur and to screen for potential drugs; they are an alternative to the use of animals in research.

Microbes may just be the next diet craze. Researchers have programmed bacteria to generate a molecule that, through normal metabolism, becomes a hunger-suppressing lipid. Mice that drank water laced with the programmed bacteria ate less, had lower body fat and staved off diabetes -- even when fed a high-fat diet -- offering a potential weight-loss strategy for humans.

If every new car made in the United States had a built-in blood alcohol level tester that prevented impaired drivers from driving the vehicle, how many lives could be saved, injuries prevented, and injury-related dollars used for something else?

The functional differences between autistic and non-autistic brains have been isolated for the first time, following the development of a new methodology for analyzing MRI scans.

Adapting to climate change could have profound environmental repercussions, according to a new study from the University of East Anglia.

Research in Nature Climate Change reveals that adaptation measures have the potential to generate further pressures and threats for both local and global ecosystems.

Lead researcher Dr Carlo Fezzi, from UEA's School of Environmental Sciences, said: "Climate change is a just a little bit more complicated than we previously thought. We need to take into account not only the direct impact of climate change, but also how people will respond to such change - the impact of adaptation.

"This is a whole new dimension to the climate change adaptation debate."

The first blood test for osteoarthritis could soon be developed, thanks to research by the University of Warwick.

The research findings could potentially lead to patients being tested for osteoarthritis and diagnosed several years before the onset of physical symptoms.

Conducted by the University's Medical School, the research identified a biomarker linked to both rheumatoid and osteoarthritis.

Whilst there are established tests for rheumatoid arthritis (RA), the newly identified biomarker could lead to one which can diagnose both rheumatoid arthritis and osteoarthritis (OA).

A plant scientist from The Australian National University (ANU) has called for the United Nations to guarantee free and open access to plant DNA sequences to enable scientists to continue work to sustainably intensify world food production.

Dr Norman Warthmann, a plant geneticist at the ANU Research School of Biology, has lodged a submission with the UN, which is currently considering issues to include in its 2015 Global Sustainable Development Report.

Food security depends on an acceleration in plant breeding, which could be threatened by private companies restricting access to genomic information, Dr Warthmann said.

Sipuleucel-T (trade name Provenge) has been approved since September 2014 for men with metastatic prostate cancer who have few or no symptoms and do not yet require chemotherapy. In the dossier assessment conducted by the German Institute for Quality and Efficiency in Health Care (IQWiG) in January 2015, no added benefit could be derived for sipuleucel-T.

In an addendum, the Institute now examined information subsequently submitted by the manufacturer in the commenting procedure: According to the findings, there is an indication of added benefit; however, the extent is non-quantifiable.

Mortality: data in the dossier incomplete and not interpretable

A new international study casts doubt on the leading theory of what causes ice ages around the world -- changes in the way the Earth orbits the sun.

The researchers found that glacier movement in the Southern Hemisphere is influenced primarily by sea surface temperature and atmospheric carbon dioxide rather than changes in the Earth's orbit, which are thought to drive the advance and retreat of ice sheets in the Northern Hemisphere.

The findings appear in the journal Geology. A PDF is available on request.

Scientists should reduce antibiotic use in lab experiments - according to a researcher at the University of East Anglia.

Microbiology, molecular biology and genetic research such as the Human Genome Project use antibiotics in experiments.

But it all adds to the global problem of antibiotic resistance according to Dr Laura Bowater, from UEA's Norwich Medical School.

A new article published today in the Journal of Antimicrobial Chemotherapy highlights the problem.

Dr Bowater said: "The discovery of antibiotics was heralded as a magic bullet for modern medicine. Using antibiotics in research has transformed scientific discovery. But now antibiotic resistance is a catastrophic threat -and it threatens the achievements of modern medicine.