A well known professor of analog circuit design and theory once said "all models are wrong".   Analog design is particularly rewarding and challenging, I believe, for this very reason.  Those words have echoed in my mind during many junctures in my journeys to learn something about the physical world.  Whether you are a theorist, phenomenologist, experimentalist or some combination of these, this fact is inescapable.
I am fascinated by how concepts of everyday life leak into all scientific thought, whether it be an elementary concept in engineering or within the confines of some rarefied physical theory.  And this is a topic I hope to write much about.

The Valentine's Day lovefest on this site - who says scientists aren't warm and fuzzy? - is spectacular. You can learn about the chemistry of love with Valentine's Day science for women, easy solutions for the languishing lothario (personal favorites at the moment - "Roses are red, violets are blue. You and me we will stick like clay," and "I wanna be your Viking cleaner breathing in your dust.

Scientists at the University of North Carolina at Chapel Hill say they have helped develop a new genomic test that can help clinicians predict which breast cancer patients are most likely to survive the disease and which treatments may be most effective in increasing those chances of survival.

By specifically measuring the activity level of a small subset of the 20,000 plus genes that may be “turned on” or “turned off” within each tumor, this genomic test can give patients a more accurate picture of how their disease might progress.

Coming up on Darwin's birthday, a lot is written about natural selection by non-biologists because opponents of evolution prefer to believe that biology stopped in 1859.  Criticizing Darwin and Natural Selection is a lot easier if you ignore the 20th and 21st centuries.

And that's okay, if the goal is a culture war rather than a science discussion, because even in Darwin's time it wasn't all balloons and ponies for Natural Selection.  It was years later that evolutionary biology got help from an understanding of genetics and Natural Selection became accepted after rigorous scientific investigation.  
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Not sure who to date? Garth Sundem answers it in The Valentine's Day Man-O-Meter. Be sure to take it as gospel because he never just makes stuff up.

If you're still unsure who to pursue, you may be looking in the wrong places. This study says We Want To Date People Slightly More Attractive Than We Are. How, then, does anyone get a date? It's another mystery of love.

One of the weaknesses of using a surname as a guide in understanding genetic characteristcs has been the belief that 1 in 10 births were the result of infidelity - so the name is not only an incorrect characteristic but could even be deceptive.

Not, so, says a study funded by the Wellcome Trust published this week in the journal Molecular Biology and Evolution, which may help genealogists create more accurate family trees even when records are missing. It suggests that the often quoted "one in ten" figure for children born through infidelity is unlikely to be true.

Sky diving and base jumping are not for everyone. However, for certain people, the more risk and adrenaline involved in an activity, the better! What draws some people to daredevil behavior while others shy away from it? Psychologists Jane E. Joseph, Xun Liu, Yang Jiang and Thomas H. Kelly from the University of Kentucky, along with Donald Lyman of Purdue University were interested in testing how the brains of sensation-seekers differ from those of us who avoid risky behavior.

Scientists have sequenced over seventy strains of yeast, the greatest number of genomes for any species.  The basic machinery of yeast is surprisingly similar to that of humans, and the project is already helping experts to develop the tools necessary for studying human genetic variation. Yeast can also be used to develop and test new drugs, such as for cancer. 

It also gave us a clever way to finagle the title and remind you about Darwin Day tomorrow - the 200th anniversary of his birth.   And, if you are  an American Republican, it's also the 200th birthday of the first Republican President, Abraham Lincoln.    But we're a science site so we'll focus on the yeast.

Roughly 10 million years ago, a major genetic change occurred in a common ancestor of gorillas, chimpanzees, and humans. Segments of DNA in its genome began to form duplicate copies at a greater rate than in the past, creating an instability that persists in the genome of modern humans and contributes to diseases like autism and schizophrenia. But that gene duplication also may be responsible for a genetic flexibility that has resulted in some uniquely human characteristics.

What does uncovering the true authorship of plays attributed to Shakespeare have to do with identifying our genetic ancestors or classifying new life forms? All involve the comparative analysis of long sets of data and all will benefit from a unique new analytical tool developed by researchers at the Lawrence Berkeley National Laboratory.