Gestational age has long been the factor most commonly used to predict whether an extremely low-birth-weight infant survives and thrives, but four additional factors that can help predict a preemie’s outcome have been identified by the National Institutes of Health Neonatal Research Network.

Birth weight, gender, whether the baby is a twin and whether the mother was given antenatal steroid mediation to aid the baby’s lung development are all factors that affect survivability and risk of disability, according to an article in the New England Journal of Medicine by a consortium of researchers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. The 19-center network includes Yale School of Medicine and Yale-New Haven Hospital.

Maturity, in some respects, brings diminished possibilities. As a fertilized egg cell repeatedly divides to grow into a mature animal, most of the resulting cells become ever more specialized.

But a small number of cells, known as stem cells, remain uncommitted even as they spawn more specialized progeny. The most versatile stem cells, taken from days-old embryos, are able to form any cell type — but studying them in people is controversial.

Even in adults, however, other types of stem cells persist that have a more limited repertoire. Some replace specific cells as they wear out; others help to rebuild damaged tissues. Still other stem cells are suspected by some scientists of starting or maintaining cancers.

Now team of researchers led by scientists at Cold Spring Harbor Laboratory have for the first time identified stem cells that allow the pituitary glands of mice to grow even after birth.

Most people know that restaurants are inspected regularly, but many assume that regularity means 5-12 times per year rather than the once that is actually the case. That's one finding in an article published in the June 2008 American Journal of Preventive Medicine. It found that the public is generally unaware of the frequency of restaurant inspections and the consequences of poor inspection results.

Foodborne diseases cause an estimated 76 million illnesses in the U.S. each year with about half associated with restaurant meals. More than 70 billion meals per year are purchased in restaurants in the U.S., accounting for 47% of total food expenditure. Therefore, preventing restaurant-associated foodborne disease is an important task of public health departments.

Jean Piaget, founder of genetic epistemology and key researcher in child development psychology, showed that kids attribute “life status” to all things that move on their own, like bikes or clouds, and even 10-year-olds have difficulty understanding the nature of a 'living' thing.

Understanding the concept of a living thing is a late developmental achievement, he stated.

New research by Northwestern University psychologist Florencia Anggoro and colleagues Sandra Waxman and Doug Medin proposes that the way in which “alive” and other biological concepts are named within a given language also shapes their understanding and acquisition in children.

The researchers compared children ages 4 to 9 speaking English and Indonesian, a pair of languages with an intriguing difference - in English, but not Indonesian, the term 'animal' is polysemous, or has more than one meaning: one sense includes all animate objects (the animal kingdom) while the other excludes humans (‘don’t eat like an animal!’)

Researchers at the University of Cincinnati and Florida State University have confirmed evidence of domesticated sunflowers in Mexico — 4,000 years before what had been previously believed.

“People sometimes ask “What is the big deal about sunflower?” says David Lentz, professor of biological sciences and executive director of the Center for Field Studies in the McMicken College of Arts & Sciences at the University of Cincinnati (UC).

It's legal, it's gaining popularity among teenagers and young adults and it's one of the most potent hallucinogens around.

Brain-imaging studies performed in animals at Brookhaven National Laboratory have provided researchers with clues about why this increasingly popular recreational drug that causes hallucinations and motor-function impairment in humans is abused. Using trace amounts of Salvia divinorum – also known as “salvia,” a Mexican mint plant that can be smoked in the form of dried leaves or serum – Brookhaven scientists found that the drug’s behavior in the brains of primates mimics the extremely fast and brief “high” observed in humans.

Women who have used Fosamax are nearly twice as likely to develop the most common kind of chronically irregular heartbeat (atrial fibrillation) than are those who have never used it, according to research from Group Health and the University of Washington published in the April 28 Archives of Internal Medicine.

Merck markets Fosamax, the most widely used drug treatment for the bone-thinning disease osteoporosis, explained study leader Susan Heckbert, MD, PhD, MPH, a professor of epidemiology and scientific investigator in the Cardiovascular Health Research Unit at the University of Washington. The Food and Drug Administration (FDA) approved the first generic versions (called alendronate) in February.

A widely used class of diabetes medications appears to be associated with an increased risk for fractures, according to a report in the April 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

“The insulin-sensitizing thiazolidinediones are a relatively new and effective class of oral antidiabetic agents that have gained wide use in clinical conditions characterized by insulin resistance,” the authors write as background information in the article. Two drugs in this category, pioglitazone and rosiglitazone, account for 21 percent of oral diabetes medications prescribed in the United States and 5 percent of those in Europe. Recent studies have suggested that these therapies may have unfavorable effects on bone, resulting in slower bone formation and faster bone loss.

Young women who took the commonly used epilepsy drug phenytoin for one year showed significant bone loss compared to women taking other epilepsy drugs, according to a study published in the April 29, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology.

Researchers tested the bone health of 93 women with epilepsy who were between the ages of 18 and 40 and were taking the epilepsy drugs phenytoin, carbamazepine, lamotrigine or valproate. Bone mineral density was measured at the spine and two areas of the hip, (the femoral neck and total hip) at the beginning of the study and one year later. Researchers also evaluated each woman’s nutrition and physical activity, along with other factors that affect bone health.

New heart research published inNature Genetics reveals how a gene called osteoglycin (Ogn), which had not previously been linked with heart function, plays a key role in regulating heart growth. The study suggests that the gene can behave abnormally in some people, and that this can lead to the heart becoming abnormally enlarged.

The researchers hope that through understanding how enlarged hearts are linked to the workings of genes like Ogn, they will be able to develop new treatments for the condition, which affects a large proportion of those with high blood pressure, obesity and diabetes.

Scientists believe that enlarged hearts are caused by a combination of genetic factors and external stimuli such as high blood pressure and obesity. However, the role played by genes has remained largely unknown.