An international collaboration is creating an innovative "freely-accessible, high resolution" digital interactive archive of William Shakespeare's pre-1641 quartos; living artifacts that tell the story of how Shakespeare's Hamlet, Henry V, King Lear, Midsummer Night's Dream, and Romeo and Juliet, to name just a few, first circulated.

The University of Maryland's Institute for Technology in the Humanities (MITH) Director Neil Fraistat says, "The quartos themselves offer crucial evidence about what actually was performed" by Shakespeare's troupe.

Because Shakespeare himself did not authorize a printed edition of his plays, what was published at the time represented what others heard, memorized or took from the marked-up "foul papers" of a particular production.

Of the almost 25,000 human genes science that have been identified, half are believed to be silent at any particular time and activated only when needed.

Perhaps not, says Andre Ptitsyn, of the Center for Bioinfomatics at Colorado State University. He says he has discovered that current tools cannot measure extraordinarily low levels of gene expression signals so genes may not be turned off, but instead have undetected functioning.

"Genes that we have believed to be silent are actually whispering," said Ptitsyn, who a applied a common physics principle to find oscillating patterns of gene expression in genes previously thought to be shut off.

An epidemiological study in Psychotherapy and Psychosomatics by H.U. Wittchen and collaborators at the University of Dresden examined the 10-year natural course of panic attacks (PA), panic disorder (PD) and agoraphobia (AG) in the first three decades of life, their stability and their reciprocal transitions.

DSM-IV syndromes were assessed via Composite International Diagnostic Interview - Munich version in a 10-year prospective-longitudinal community study of 3,021 subjects aged 14-24 years at baseline. At the end of the study, incidence patterns for PA (9.4%), PD (with and without AG: 3.4%) and AG (5.3%) revealed differences in age of onset, incidence risk and gender differentiation.

The "Large Molecule Heimat" is a very dense, hot gas clump within the star forming region Sagittarius B2. In this source of only 0,3 light-year diameter, which is heated by a deeply embedded newly formed star, most of the interstellar molecules known to date have been found, including the most complex ones such as ethyl alcohol, formaldehyde, formic acid, acetic acid, glycol aldehyde (a basic sugar), and ethylene glycol.

Starting from 1965, more than 140 molecular species have been detected in space, in interstellar clouds as well as in circumstellar envelopes. A large fraction of these molecules is organic or carbon-based. A lot of attention is given to the quest for so-called "bio"-molecules, especially interstellar amino acids. Amino acids, the building blocks of proteins and therefore key ingredients for the origin of life, have been found in meteorites on Earth, but not yet in interstellar space.

Astrophysicists say may be one step closer to understanding how new planets form. A circumstellar disk with telltale signs of planet formation around the star AB Aurigae could be a new planet in the works.

Ben R. Oppenheimer, assistant curator in the American Museum of Natural History's Department of Astrophysics, and colleagues have used the Lyot Project coronograph attached to a U.S. Air Force telescope on Maui, Hawaii, to construct an image of material that seems to be coalescing into a body from the gas and dust cloud surrounding AB Aurigae, a well-studied star.

The body is either a planet or a brown dwarf - something with mass between a star or a planet. Brown dwarfs have been found orbiting stars since a team that included Oppenheimer first discovered one in 1995.

Scientists have reconstructed changes in Earth’s ancient ocean chemistry from about 2.5 to 0.5 billion years ago and say that a deficiency of oxygen and the heavy metal molybdenum in the ancient deep ocean may have delayed the evolution of animal life on Earth for nearly 2 billion years.

This research was motivated by a review article published in Science in 2002 by Ariel Anbar, one of the authors of the study and an associate professor at Arizona State University with joint appointments in the Department of Chemistry and Biochemistry and Andy Knoll, a colleague at Harvard University. Knoll was perplexed by the fact that eukaryotes didn’t dominate the world until around 0.7 billion years ago, even though they seemed to have evolved before 2.7 billion years ago.

The brain can sense the calories in food, independent of the taste mechanism, researchers have found in studies with mice. Their finding that the brain’s reward system is switched on by this “sixth sense” machinery could have implications for understanding the causes of obesity.

For example, the findings suggest why high-fructose corn syrup, widely used as a sweetener in foods, might contribute to obesity.

In their experiments, Ivan de Araujo and colleagues genetically altered mice to make them “sweet-blind,” lacking a key component of taste receptor cells that enabled them to detect the sweet taste.

Nearly ten years ago an article published in Science [Lockless SW, Ranganathan R (1999) Science 286:295–299] got a lot of attention. It described a method of demonstrating signal transfer in proteins by comparing their amino acid sequence.

The authors recorded a statistical method of showing how certain parts of proteins change together through evolution, i.e. if a change had taken place in one part a change simultaneously took place in another part of the protein. They found a network of parts that seemed to belong together and, within this network, signal transfer was deemed to take place.

In a new PNAS article, Uppsala researchers present results of experiments they say contradicts that theory.

A new study in the April issue of Psychological Science sought to examine whether individuals are motivated to increase their level of anger when they expect to complete a confrontational task, where anger might enhance performance.

Psychologists Maya Tamir and Christopher Mitchell of Boston College, and James Gross of Stanford University told the study participants that they will either play a computer game that is confrontational (“Soldier of Fortune” – a first person shooter game where killing enemies is your primary goal) or one that is not confrontational (“Diner Dash”—a game in which players guide a waitress serving customers). They were then asked to rate the extent to which they would like to engage in different activities before playing the game.

March 19,2008 marked the brightest ever cosmic explosion observed from Earth ( see Georg von Hippel's article here and the news article here). The outburst denoted as GRB 080319B was probably the death of a massive star leading to the creation of a black hole.

For the first time the birth of a black hole has been filmed. Cameras of the "Pi of the Sky" project recorded this remarkable event with a 4 minutes sequence of 10-second images. In under 20 seconds the object became so bright that it was visible with the naked eye. Then it began fading and in 4 minutes was 100 times fainter. At that time the observation was taken over by larger telescopes.