Folding is very important in human brain development because some of the worst neurological problems such as schizophrenia, autism and lissenchephaly (smoothness of the cortex, found with severe retardation) are associated with abnormal brain folding.
On the other hand, Albert Einstein's abnormally folded brain made him a genius
Larry A.Taber, Ph.D., the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Phillip Bayly, Ph.D., Hughes Professor of Mechanical Engineering, are examining mechanical and developmental processes that occur in the folding of the brain's surface, or cortex, which gives the higher mammalian brain more surface area (and hence more intellectual capacity) than a brain of comparable volume with a smooth surface.