Recent legislation is encouraging clinical trials in children, including the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act. Yet clinical trials in children commonly go either uncompleted or unpublished, finds a comprehensive study conducted by researchers at Boston Children's Hospital. Results were published online August 4 by the journal Pediatrics.
In all, 19 percent of trials were discontinued early, and 30 percent of completed trials remained unpublished in the medical literature several years later. "We feel there is a lot of inefficiency and waste that could be addressed," says senior investigator Florence Bourgeois, MD, MPH, of Boston Children's Hospital.