At least half of Parkinson's disease patients experience psychosis at some point during the course of their illness, and physicians commonly prescribe antipsychotic drugs, such as quetiapine, to treat the condition. However, a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania, the University of Michigan Medical School, and the Philadelphia and Ann Arbor Veterans Affairs (VA) Medical Centers and suggests that these drugs may do significantly more harm in a subset of patients. The findings will be published in the March 21, 2016 issue of JAMA Neurology.

Leonard: "The holographic principle suggests that what we all experience every day in three dimensions may really just be information on a surface located at the farthest reaches of our cosmos. So it's possible that our lives are really just acting out a painting on the largest canvas in the universe." 
Penny: "Hmmm..."

Is our universe holographic? Is what is happening in the universe somehow encoded on its boundary? Are we 3D renderings of some distant 2D image? Black hole physics certainly suggests so. But how does such an encoding work? Can we visualize a system that "just acts out" a painting on its boundary?

ITHACA, N.Y. - According to a recent study, the size of a common ground-nesting bee - an important crop pollinator - has grown smaller in heavily farmed landscapes.

The link between intensive agriculture and the size of Andrena nasonii bees has important implications for how farmers might diversify these landscapes to benefit bees. It also points out yet another potential threat to pollinators, along with mites, pesticides and loss of habitat.

Scientists at the Max Planck Institute for Extraterrestrial Physics (MPE) have revisited the all-sky survey carried out by the ROSAT satellite, to create a new image of the sky in at X-ray wavelengths. Along with this a revised and extended version of the catalogue of bright and faint point-like sources will be released. The now published "2RXS catalogue" provides the deepest and cleanest X-ray all-sky survey to date, which will only be superseded with the launch of the next generation X-ray survey satellite, eROSITA, currently being completed at MPE.

Humans have put yeast to work for thousands of years to make bread, beer, and wine. Wild strains of yeast are also found in the natural fermentations that are essential for chocolate and coffee production. But, as new genetic evidence reported in the Cell Press journal Current Biology on March 24 shows, the yeasts associated with coffee and cacao beans have had a rather unique history.

In comparison to the yeasts found in vineyards around the world, the new work shows that those associated with coffee and cacao beans show much greater diversity. The findings suggest that those differences may play an important role in the characteristics of chocolate and coffee from different parts of the world.

So, if you take literally what Patricia Hunt, Ph.D. and colleagues reported in the new issue of the Journal of Clinical Endocrinology and Metabolism, you could only conclude that two chemically unrelated, so-called endocrine disruptors alone were costing the EU $1.63 billion in female reproductive disorders. That is, unless they neglected to add the VAT, in which case it will be more.

Routine mammography--widely recommended for breast cancer screening--may also be a useful tool to identify women at risk for heart disease, potentially allowing for earlier intervention, according to a study scheduled for presentation at the American College of Cardiology's 65th Annual Scientific Session.

New lip-reading technology developed at the University of East Anglia (UEA) could help in solving crimes and provide communication assistance for people with hearing and speech impairments.

The visual speech recognition technology, created by Dr Helen L. Bear and Prof Richard Harvey of UEA's School of Computing Sciences, can be applied "any place where the audio isn't good enough to determine what people are saying," Dr Bear said.

As organic chemistry evolved, techniques for catalyzing hydrocarbons advanced and one by one a method was created for their manipulation. Ethane, propane, butane, pentane -- all the alkanes followed a similar pattern and their reactions had predictable results. Only one alkane-methane- refused to follow suit and this confounded chemists for decades. Methane had been just too difficult to work with; its C-H bond could not be manipulated. Using a new hybrid breed of computational and experimental chemistry, an international team of chemists, led by IBS Center for Catalytic Hydrocarbon Functionalizations Associate Director Mu-Hyun Baik, was able to solve a puzzle that has been dubbed a "Holy Grail reaction" and devise a method for catalyzing reactions with methane.

Viruses that infect bacteria are among the most abundant life forms on Earth. Indeed, our oceans, soils and potentially even our bodies would be overrun with bacteria were it not for bacteria-eating viruses, called bacteriophages, that keep the microbial balance of ecological niches in check.

Now, a new study at Washington University School of Medicine in St. Louis suggests that bacteriophages made of RNA -- a close chemical cousin of DNA -- likely play a much larger role in shaping the bacterial makeup of worldwide habitats than previously recognized.