The Molecular Microbiology Research Group in the UAB's Department of Genetics and Microbiology describes for the first time, in a work published in PLOSone, a model of behaviour of a bacterial colony that shows how the colony protects itself against toxic substances, like antibiotics, during the colonisation process.
The researchers have determined that alteration of the equilibrium between two proteins of Salmonella enterica in the presence of antibiotics leads to the disorganisation of the structures that allow the population to spread, which in turn stops the progress of the cells in the bacterial colony that are nearest to harmful concentrations of antibiotic, while the rest spread into areas with lower concentrations.