The drug trastuzumab (Herceptin) is used to treat HER2-positive breast cancer (a type of breast cancer that overexpresses the HER2 gene and accounts for about 25% of all breast cancers). Trastuzumab therapy improves the chances of survival; however, it has deleterious side effects and is expensive. Thus, it is important to accurately determine the patient’s HER2 status.

The challenge is to develop a testing strategy that is both accurate and economical. A false-negative test result can mean a woman will not receive a life-prolonging drug, and a false-positive result can lead to unnecessary, expensive drug treatment.

Pacific Northwest National Laboratory geologists have put out a call for teeth tusks, femurs and any and all other parts of extinct mammoths left by massive Ice Age floods in southeastern Washington.

New evidence on sex differences in people’s brains and behaviors emerges with the publication of results from the British Broadcasting Corporation’s (BBC) Sex ID Internet Survey. Survey questions and tests focused on participants’ sex-linked cognitive abilities, personality traits, interests, sexual attitudes and behavior, as well as physical traits. The Archives of Sexual Behavior¹ has devoted a special section in its April 2007 issue to research papers based on the BBC data.

Diabetes researchers, investigating how the body supplies itself with insulin, discovered to their surprise that adult stem cells, which they expected to play a crucial role in the process, were nowhere to be found. Many researchers had proposed that adult stem cells develop into insulin-producing cells, called beta cells, in the pancreas.

Instead, the beta cells themselves divide, although slowly, to replenish their own population.

Researchers at the University of Illinois have developed a simple and economical technique for imaging and mapping fruit fly chromosomes. This new approach will enable them to construct the first accurate map of the chromosomes and tease out the secrets hidden in their stripes.

Don't feel bad if you want to be part of the "in" crowd. It may be hardwired in our brain cells.

Even newborn brain cells reach out to mature brain cells that are already well connected within the established circuitry, report scientists at the Salk Institute for Biological Studies in the online edition of Nature Neuroscience.

Increasing the amount of SUMO, a small protein in the brain, could be a way of treating diseases such as epilepsy and schizophrenia, reveal scientists at the University of Bristol, UK. Their findings are published online today in Nature.

The brightest stellar explosion ever recorded may be a long-sought new type of supernova, according to observations by NASA's Chandra X-ray Observatory and ground-based optical telescopes. This discovery indicates that violent explosions of extremely massive stars were relatively common in the early universe, and that a similar explosion may be ready to go off in our own Galaxy.

Coral reefs, among Earth's richest ecosystems, traditionally teem with an abundance of life. But in recent years, corals have been dying in droves. Scientists suspect a variety of factors, ranging from accidental damage from fishing activity to the effects of polluted runoff from land.

One threat that appears to be growing dramatically in Australia's famed Great Barrier Reef is white syndrome, a disease that is spreading rapidly, leaving stripes of dead corals like ribbons of death in its wake.

A new, highly destructive strain of wheat stem rust is continuing to evolve and has the potential to devastate wheat production worldwide, say plant pathologists with The American Phytopathological Society (APS).