Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, researchers at Norris Cotton Cancer Center and the Geisel School of Medicine at Dartmouth have found. The findings, published in OncoImmunology, demonstrate a new approach in immunotherapy that can be applied in a variety of cancer types.
"By introducing an attenuated and safe form of the bacteria Listeria monocytogenes (Lm), in collaboration with Aduro Biotech Inc., we found that the attenuated bacteria is taken up by the immunosuppressive cells and transforms them from cells that protect the tumor into cells that attack the tumor," said Steve Fiering, PhD, lead author of the study.