Simple nucleotide polymorphisms (SNPs), are single variations affecting only one nucleotide or base of the genomic sequence. Despite humans sharing 99.9% of the genome sequence, there are still 3 million genetic variations –which make us different from one another– 90% of which are due to SNPs.

An international collaboration has performed a large-scale study on genetic differences between patients infected by HIV, and is the first study of this kind in the field of infectious disease.

Results point to two gene variants related to the immune system. More precisely, these variations are in a genetic region responsible for the determination of immune response capacity against a number of infectious diseases, including AIDS.

Experiments using pigs genetically engineered for compatibility with the human immune system have raised hopes that cross-species transplantation could soon become an option for patients with diabetes and other currently incurable diseases.

However, scientific hurdles remain before the ultimate goal of inducing long-term tolerance of animal tissues and organs in human recipients, according to Dr. David Cooper of Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center.

"The potential benefits of successful xenotransplantation to large numbers of patients with very differing clinical conditions remain immense, fully warranting the current efforts being made to work towards its clinical introduction," he writes.

A new substance analyzer has been developed by the All-Russian Scientific Research Institute of Technical Physics and Automation in Moscow.

Its functionality is to automatically determine the content of up to 20 chemical elements in the periodic table between calcium and bismuth but in a package small enough to fit in a rucksack.

Basically it runs an X-ray generator over the surface of the core, stimulating all atoms of the specimen within a radius of slightly less than 2 centimeters. It will then independently measure “secondary” fluorescent radiation: the atoms stimulated by X-ray, when coming back to the quiescent state, exude excess energy in the form of radiation and the device records that radiation.

In the search for better ways of treating children with brain cancer the study, a twelve-year research effort carried out by the Children’s Cancer and Leukaemia Group at The University of Nottingham revealed that a significant proportion of children under the age of three, with the brain tumor ependymoma, can be spared the effects of radiotherapy by using chemotherapy — without compromising their chances of survival.

Experts in the field of childhood cancer recognise that radiotherapy can be harmful to a young child’s developing brain. It can affect IQ, short term memory, growth and puberty. The effective treatment of patients under the age of five remains, say the researchers, one of the more difficult tasks in pediatric oncology.

In what advocates hailed as a major advance for scientific communication, the U.S. House of Representatives yesterday approved a measure directing the National Institutes of Health (NIH) to provide free public online access to agency-funded research findings within 12 months of their publication in a peer-reviewed journal. With broad bipartisan support, the House passed the provision as part of the FY2008 Labor, HHS, and Education Appropriations Bill.

Removing invasive predators from island breeding colonies could save more seabirds for less cost than reductions in fishing, a study of Australia’s Eastern Tuna and Billfish Fishery (ETBF) has found.

According to one of the authors of a paper on the findings in the August edition of Frontiers in Ecology and Environment, CSIRO scientist Dr Chris Wilcox, a major challenge for fisheries worldwide is to reduce their impact on ‘bycatch’ species such as seabirds.

“Australian Commonwealth fisheries have made strong efforts towards reducing bycatch, including modifying fishing gear and restricting areas and periods of fishing, but these measures are not always effective, leading to costly interventions such as fishery closure,” Dr Wilcox says.

Faster growth, darker leaves, a different way of branching - wild varieties of the plant Arabidopsis thaliana are often substantially different from the laboratory strain of this small mustard plant, a favorite of many plant biologists.

Which detailed differences distinguish the genomes of strains from the polar circle or the subtropics, from America, Africa or Asia has been investigated for the first time by research teams from TÃbingen, Germany, and California led by Detlef Weigel from the Max Planck Institute for Developmental Biology.

People with bipolar disorder – or manic depression – suffer from an accelerated shrinking of their brain, researchers at the University of Edinburgh have found.

The study shows for the first time that bipolar disorder – a condition characterised by periods of depression and periods of mania – is associated with a reduction in brain tissue and proves that the changes get progressively worse with each relapse.

This discovery has implications not only for the way we research the disease, but may also impact the way this condition is treated.

At very young ages, children’s defiant behavior toward their mothers may not be a bad thing. This defiance may in fact reflect children’s emerging autonomy and a confidence that they can control events that are important to them.

Those are the findings of a new study conducted by researchers at the University of Texas at Austin and the University of Michigan.

To understand how very young children react to being controlled by their parents, the researchers videotaped 119 mostly middle-class mothers as they interacted with their 14- to 27-month-old children. Mothers were asked to have their children avoid a set of attractive toys and, when play time was over, to get their children to help them clean up those toys they had been allowed to use.

Two NASA robots are surveying a rocky, isolated polar desert within a crater in the Arctic Circle. The study will help scientists learn how robots could evaluate potential outposts on the moon or Mars.

The robots, K10 Black and K10 Red, carry 3-D laser scanners and ground-penetrating radar. The team arrived at Haughton Crater at Devon Island, Canada, on July 12 and will operate the machines until July 31. Scientists chose the polar region because of the extreme environmental conditions, lack of infrastructure and resources, and geologic features. Also, Haughton Crater is geographically similar to Shackleton Crater at the South Pole of the moon. Both are impact craters that measure roughly 12.4 miles in diameter.