Mu Delta Kappa is a key
brain receptor targets for opiates
because the mu opioid receptor is the primary target for morphine and endogenous opioids like endorphin. The delta opioid receptor shows the highest affinity for endogenous enkephalins. The kappa opioid receptor (KOR) is very interesting, but the least understood of the opiate receptor family.

Lubricants are used in motors, axels, ventilators and manufacturing machines. Although lubricants are widely used, there have been almost no fundamental innovations for this product in the last twenty years. Together with a consortium, the Fraunhofer Institute for Mechanics of Materials IWM in Freiburg has developed an entirely new class of substance that could change everything: liquid crystalline lubricant. Its chemical makeup sets it apart; although it is a liquid, the molecules display directional properties like crystals do. When two surfaces move in opposite directions, the liquid crystal molecules between the two surfaces align themselves so that the frictional resistance is extremely low. This enables nearly frictionless sliding.

The Deadliest Catch details the work travails of Bering Sea crab fishermen, but African wives of fishermen may be having adventures of their own.

The authors of a recent paper estimated that up to 60% of men and 50% of women report extra-marital partnerships in their lifetime - and they believe those numbers are under-reported, especially among women, due to cultural constraints. In reality, range estimates are so broad as to be almost meaningless but even if it's 20% it's a lot.

Schistosomiasis is a parasitic disease that infects 243million people worldwide, and kills about 200 thousand every year. Theinfection is contracted through contaminated waters, and in the developingworld, where is most common, is 2nd only to malaria in rates of infection andpublic health impact.

To make things worse, women, already one of the most vulnerable groups in these regions, often develop infertility secondary to the infection, with the parasite being a main cause for the problem in these regions . Places where female role is centred on being a mother, and gynaecological medical care is next to inexistent. 

The decision to jettison the controversial approach to dying known as the Liverpool Care Pathway was "too extreme" given that its principles were considered by proponents as the best examples of palliative care in the world, argues a senior ethicist in the Journal of Medical Ethics.

Whether an insect will have a male or female offspring depends on the weather and temperature, according to a study led by Joffrey Moiroux and Jacques Brodeur of the University of Montreal's Department of Biological Sciences.

As part of this study, which was funded by the Ouranos Consortium, Moiroux tried to understand the possible role of global warming on the relationship between crop pests and their natural enemies – parasitoids and predators. Among the issues addressed, he sought to determine whether there is an effect of "phenological asynchrony" between parasitoids and their hosts, and therefore an impact on the availability of host eggs and on pest control by their natural enemies. 

Following a genetic marker for breast cancer, the actress Angelina Jolie had a preventative double mastectomy. Cancer experts were horrified - and with good reason. About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so against doctor recommendations, so healthy women certainly should not.  And they certainly should not take medical advice from a women who wrote her first husband's name in her blood on their wedding day.
 
Yet she is not alone. Recent studies have shown an increase in women with breast cancer choosing this more aggressive surgery, called contralateral prophylactic mastectomy, which raises the question of potential over-treatment among these patients.

DOWNERS GROVE, Ill. – May 21, 2014 – According to a new systematic review article, radiofrequency ablation and complete endoscopic resection are equally effective in the short-term treatment of dysplastic Barrett's esophagus, but adverse event rates are higher with complete endoscopic resection. The article comparing the two treatments appears in the May issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

A home-based exercise program helped people with clogged leg arteries walk farther and faster, according to new research in the Journal of the American Heart Association. The program was beneficial even 12 months after participants started the program.

Previously, studies have shown that supervised exercise can improve walking and lessen the symptoms of peripheral artery disease (PAD), but this is the first to document the long-term benefits of a home-based walking program.

Newly analyzed tooth samples from the great apes of the Miocene indicate that the same dietary specialization that allowed the apes to move from Africa to Eurasia may have led to their extinction, according to results published May 21, 2014, in the open access journal PLOS ONE by Daniel DeMiguel from the Institut Catalá de Palontologia Miquel Crusafont (Spain) and colleagues.