University of Hawai'i Cancer Center researchers discovered new genetic markers associated with a fast rate of nicotine metabolism, which potentially leads smokers to smoke more, thereby, increasing their risk for lung cancer.
Dr. Loïc Le Marchand, a professor and leading epidemiologist in the UH Cancer Center's Epidemiology Program, and his colleagues, identified differences in the CYP2A6 gene that are associated with a high rate of nicotine metabolism. Smokers who have these CYP2A6 markers may smoke more cigarettes and/or inhale a greater amount of nicotine per cigarette than smokers who metabolize nicotine less rapidly, in order to maintain stable levels of nicotine in the blood.