Daniel H. Conrad, professor of microbiology and immunology at the
Virginia Commonwealth University
School of Medicine, and colleagues have uncovered a new connection between allergy and cancer that could potentially lead to therapies involving common antihistamines.
In the Journal of Leukocyte Biology, their study found that histamine, a component of the immune system that responds to allergens and foreign pathogens and is also linked to inflammation, plays a role in protecting tumors from the immune system. By blocking the production of histamine in animal models, the researchers were able to interrupt a process that promotes melanoma growth.