An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in PNAS. The protein, HMGB1, was previously hypothesized to block DNA repair, senior author Karen Vasquez, Ph.D., associate professor in M. D. Anderson's Department of Carcinogenesis at the Science Park - Research Division in Smithville, Texas.

Identification and repair of DNA damage is the frontline defense against the birth and reproduction of mutant cells that cause cancer and other illnesses.

Pinpointing HMGB1's role in repair raises a fundamental question about drugs under development to block the protein, Vasquez said. The protein also plays a role in inflammation, so it's being targeted in drugs under development for rheumatoid arthritis and sepsis.

A bizarre title, but nothing to do with the fact that I am constitutionally lazy. Rather, it is related to the war I and a colleague are attempting to wage against the way physics is (in the UK at least) treated as a form of applied mathematics. It also has direct application to astrophysics – I know one student who went to study physics at university in 2002, in large part attracted by astronomy, but after a second year including astrophysics was saying "I hate stars." He was quite reasonable at maths, but it is the way that the subject was presented that put him off.

Carbon dioxide has been getting a bad rap for the last few years, what with "Waterworld" and the IPCC's preference for French nuclear plants, but laser resurfacing appears to be an effective long-term treatment for facial wrinkles, according to a report in the July/August issue of Archives of Facial Plastic Surgery. So at least aging rich women will look good when the planet dies.

The carbon dioxide laser vaporizes water molecules inside and outside of cells, causing thermal damage to the surrounding tissue, the authors write as background information in the article. In response to this insult, the skin produces more of the protein collagen, which fills in wrinkles. "In addition to structural changes, the healing process frequently leads to pigmentary [coloring] changes," the authors write. "These changes in skin pigmentation may be desirable, such as when patients wish to remove solar evidence of aging; however, changes in pigmentation after treatment can often be a troubling adverse effect."

After completing one of the longest running experiments ever done on a lake, researchers from the University of Alberta, University of Minnesota and the Freshwater Institute, contend that nitrogen control, in which the European Union and many other jurisdictions around the world are investing millions of dollars, is not effective and in fact, may actually increase the problem of cultural eutrophication.

The dramatic rise in cultural eutrophication—the addition of nutrients to a body of water due to human activity that often causes huge algal blooms, fish kills and other problems in lakes throughout the world—has resulted from increased deposits of nutrients to lakes, largely from human sewage and agricultural wastes.

If you really love the outdoors, you should never experience it, according to a new study by conservation biologists from the University of California, Berkeley.

The study compared parks in the San Francisco Bay Area that allow only quiet recreation such as hiking or dog walking with nearby nature reserves that allow no public access. Evidence of some native carnivore populations - coyote and bobcat - was more than five times lower in parks that allow public access than in neighboring reserves where humans don't tread, the researchers report.

The dearth of these animals in the parks carries implications beyond just these species. Since the carnivores in the study are often the top predators in their areas, these animals also shape the rest of their surrounding ecosystems. The flight of large animals from heavily visited parks for more serene surroundings could, in turn, influence populations of small animals and plants, the researchers said.

Elvira Fortunato and colleagues from the Centro de Investigação de Materiais (Cenimat/I3N), at Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, made the first Field Effect Transistor (FET) with a paper «interstrate» layer.

There is an increased interest in the use of biopolymers for low-cost electronic applications. Since cellulose is the Earth’s major biopolymer, some international teams have reported using paper as the physical support (substrate) of electronic devices but no one had used paper as an interstrate component of a FET.

The electrical performance of the new device rivals oxide-based thin film transistors (TFTs) produced on glass or crystalline silicon substrates. Full results will be published in September's in IEEE Electron Device Letters.

Oxytocin is a neuropeptide that is secreted by the body during massage, childbirth and breastfeeding to induce a calming, analgesic effect. Animal studies have also shown that oxytocin promotes social interaction, such as during the courting process. The hormone has a direct influence on the amygdala, a brain area that is important for social interaction and for identifying immediate emotional threats.

Swedish and British scientists have shown using functional magnetic resonance imaging (fMRI) that the hormone oxytocin can inhibit feelings of anxiety in specific individuals. Their discovery might lead to a better understanding and the improved treatment of psychiatric affections in which people feel distressed when meeting others, such as in cases of autism and social phobia.

Taking the epilepsy drug topiramate alone or along with other epilepsy drugs during pregnancy may increase the risk of birth defects, according to a study published in the July 22, 2008, issue of Neurology.

Research has shown that many epilepsy drugs increase the risk of birth defects, but little research has been done on topiramate. Studies have shown that topiramate increases the risk of birth defects in animals. Maintaining effective epilepsy treatment during pregnancy is crucial because seizures may cause harm to the fetus.

Even if you're a caricature of the worst kind of maintenance person, such as Groundskeeper Willie in "The Simpson", there's a lesson for real life teachers.

Apparently, the lesson is 'don't be like that.' And the rest of the Simpsons supporting cast can teach educators a thing or two as well, say two academics in their paper, “Images of the Teacher in The Simpsons: Subversive, Superficial, or Sentimental?” which was presented at “The Teacher: Image, Icon, Identity” conference in Glasgow, Scotland.

“Given the often central role that the figure of the teacher plays in ‘The Simpsons,’ there is a…rich vein that could be mined for the purposes of teacher education, whether through initial training or continuing professional development,” says Gavin Morrison, curator of the University Galleries at Texas Christian University in Fort Worth and co-author Alan Britton of the University of Glasgow.

Few things say as much about our culture as the food we eat. A new book, Glazed America: A History of the Doughnut by Paul R. Mullins, Ph.D., an Indiana University-Purdue University Indianapolis anthropologist, explores the development of America's consumer culture through our relationship with the doughnut; beloved by all but a symbol of temptation and unhealthiness to some.

It's unknown when in in pre-history someone dropped flour into oil but it happened and the ancestor of the doughnut was born. Since then, every culture has fried flour and many add something sweet to the dough.

Mullins is certainly a fan of his subject. He enjoys his doughnuts at an Indianapolis mom and pop shop which has been serving up those fried delicacies for 55 years, though he is also an avid runner who logs approximately 45 miles per week, often past that doughnut shop.