Normal yeast organisms live about a week but using a combination of dietary and genetic changes, biologists have created baker’s yeast capable of living to 800 (in yeast years) without apparent side effects.
Study leader Valter Longo of the University of Southern California and his group put baker’s yeast on a calorie-restricted diet and knocked out two genes, RAS2 and SCH9, that promote aging in yeast and cancer in humans.
“We got a 10-fold life span extension that is, I think, the longest one that has ever been achieved in any organism,” Longo said.
“I would say 10-fold is pretty significant,” said Anna McCormick, chief of the genetics and cell biology branch at the National Institute on Aging and Longo’s program officer.