A recent issue of Genome Research contains a report of the cat genome sequence (Pontius et al. 2007), adding Felis catus to the rapidly growing collection of animal genome sequences. One of the reasons that the number of mammal sequences is increasing so quickly is that there have been reduced standards for sequence coverage. To wit, the cat is one of 24 mammal species approved by NHGRI for "low redundancy" sequencing, meaning that the sequence will be covered only 2-fold (vs. up to 7x coverage in dog, chimp, human, mouse, and rat).

Of all the 'Greatest Scientific Breakthroughs' of 2007 heralded in the pages of various newspapers and magazines this past month, perhaps the most unsung one is the entrance of next-generation DNA sequencing onto the stage of serious research. Prior to this year, the latest sequencing technologies were limited in their usefulness and accessibility due to their cost and a steep technical learning curve. That's now changing, and a group of recent research papers gives us a hint of just how powerful this new technology is going to be. Not only will next-generation sequencing be the biggest change in genomics since the advent of microarray technology, but it may also prove to be the first genome-scale technology to become part of every-day medical practice.

Recently there has been some discussion in the blogosphere about student-advisor relationships in science.

Four years of observations from the European Space Agency’s Integral (INTErnational Gamma-Ray Astrophysics Laboratory) satellite may have cleared up one of the most vexing mysteries in our Milky Way: the origin of a giant cloud of antimatter surrounding the galactic center.

As reported by an international team in the January 10 issue of Nature, Integral found that the cloud extends farther on the western side of the galactic center than it does on the eastern side.

When people in a University of North Carolina at Chapel Hill study were told that anorexia nervosa had a biological or genetics-based cause they were less likely to put any personal accountability on anorexics than when they were told it was personal or cultural.

That makes sense. A disease that is egalitarian and exculpatory like a genetics or biological mutation is different than a syndrome. We can't blame kids with Autism for having Autism, though we do teach them to moderate their behavior - and that's a key point.

Anorexia nervosa is characterized by an obsessive desire to be thin and results in self-starvation and related medical complications.

The last fish you ate probably came from the Bering Sea. At present, the Bering Sea provides roughly half the fish caught in U.S. waters each year and nearly a third caught worldwide.

While the basic dynamics of a 'greenhouse ocean' are not well understood, marine ecologists writing in Marine Ecology Progress Series expressed concern that, if their predictions are true, a warming ocean would lead to a much different ecology there.

“All the fish that ends up in McDonald’s, fish sandwiches — that’s all Bering Sea fish,” said USC marine ecologist Dave Hutchins.

An international research team has discovered that a magnetic field can interact with the electrons in a superconductor in ways never before observed.

Andrea D. Bianchi, the lead researcher from the Université de Montréal, explains in the January 11 edition of Science magazine what he discovered in an exceptional compound of metals – a combination of cobalt, indium and a rare earth – that loses its resistance when cooled to just a couple of degrees above absolute zero.

“When subjected to intense magnetic fields, these materials produce a completely new type of magnetic tornado that grows stronger with increasing fields rather than weakening,” said Prof. Bianchi. “The beauty of this compound is how we can experiment without breaking it.”

New ways to make sure people are adequately informed about the risks and benefits of taking part in a clinical trial can be field-tested for effectiveness as vigorously as new medical treatments themselves, a study led by a Johns Hopkins bioethicist suggests.

Informed consent, a mainstay of ethical clinical trials, is the process by which potential research subjects are asked to decide whether to participate in research.

A new study by University of Colorado at Boulder researchers indicates older, multi-year sea ice in the Arctic is giving way to younger, thinner ice, making it more susceptible to record summer sea-ice lows like the one that occurred in 2007.

The team used satellite data going back to 1982 to reconstruct past Arctic sea ice conditions, concluding there has been a nearly complete loss of the oldest, thickest ice and that 58 percent of the remaining perennial ice is thin and only 2-to-3 years old, said the lead study author, Research Professor James Maslanik of CU-Boulder's Colorado Center for Astrodynamics Research.

The roundworm C. elegans, a staple of laboratory research, may be key in unlocking one of the central biological mysteries: why we sleep.

Researchers at the University of Pennsylvania School of Medicine report in this week’s advanced online edition of Nature that the round worm has a sleep-like state, joining most of the animal kingdom in displaying this physiology. This research has implications for explaining the evolution and purpose of sleep and sleep-like states in animals.

In addition, genetic work associated with the study provides new prospects for the use of C. elegans to identify sleep-regulatory genes and drug targets for sleep disorders.