A group of protein kinases have been found to play an important role in embryo development and may even be a potential cancer drug target, says research led by Queen Mary University of London (QMUL) and the Francis Crick Institute, UK.
The study, published in Cell Reports, is the first description of knockouts of a whole family of protein kinases (PKN1-3) in mice and reveals roles in congenital birth defects such as spina bifida.
The team knocked out a whole kinase family but, unusually, only one member (PKN2) appeared to be important in development and warrants renewed attention.