Researchers at Johns Hopkins have discovered that two clinically different inherited syndromes are in fact variations of the same disorder. The team suggests that at least for this class of disorders, the total number and “strength” of genetic alterations an individual carries throughout the genome can generate a range of symptoms wide enough to appear like different conditions.

“We’re finally beginning to blur the boundaries encompassing some of these diseases by showing that they share the same molecular underpinnings,” says Nicholas Katsanis, Ph.D., an associate professor of ophthalmology at the McKusick-Nathans Institute of Genetic Medicine at Hopkins. “This is important progress for several reasons. First, knowing what’s going on molecularly and being able to integrate rarer conditions under common mechanisms allows us to potentially help more people at once. Second, clinicians can finally begin to offer more accurate diagnoses based on what really matters: the state of affairs at the cellular/biochemical level. In time, this will empower genetic counseling and much improved patient management.”

Tests on a ‘virtual physiological human’ (VPH) have simulated how well an HIV drug blocks a key protein in the lethal virus, say scientists in the UK. The method could pave the way to personalized drug treatments, such as for HIV patients developing resistance to their current regimes.

The human body is too complex to replicate using a single computer or even several computers strapped together. To fully simulate our inner workings, the VPH has to link networks of computers nation- and worldwide. With all this power assembled, scientists can then carry out studies of "supercomputing" proportions, such as the effects of a drug at the organ, tissue, cell and even molecular levels.

A team of Penn State University researchers is the first to demonstrate that lipid molecules in cell membranes participate in mammals' reactions to allergens in a living cell. The finding will help scientists better understand how allergy symptoms are triggered, and could contribute to the creation of improved drugs to treat them.

The team studied clusters of cholesterol-rich lipid molecules that they believe serve as platforms for the receptors that receive antibodies, the proteins that protect the body from allergens. In this case, the team examined IgE antibodies, which upon binding to their receptors initiate a cell's release of histamine--the substance that causes the unpleasant, but beneficial, mucous production, congestion, and itchiness associated with allergies.

Cannabis, the genus of flowering plants commonly known as marijuana, may create medicines that can help cure nicotine addiction, say University of Nottingham pharmacologists who have been studying the cannabis-like compounds which exist naturally in our bodies (endocannabinoids), and are exploring their potential for medical treatment. This includes treating conditions as diverse as obesity, diabetes, depression and addiction to substances like nicotine.

Scientists have known about endocannabinoids since the mid-1990s. This led to an explosion in the number of researchers looking into the future medical uses of cannabinoids and cannabis compounds.

Dr Steve Alexander, Associate Professor in the School of Biomedical Sciences, focused on a number of these projects in editing the first themed podcast for the British Journal of Pharmacology.

Interested in the strange, turn-of-the-century science and math in Thomas Pynchon's novel Against The Day? In part 2 of my primer on Pynchon's science read about the obscure conflict among mathematicians over quaternions, before modern vector analysis largely won the day. (If you missed part 1, read it here).

Science and Against The Day Part 2: Vectors and Quaternions

I. The need for algebra in more than one dimension

In Against the Day, Pynchon frequently refers to a relatively obscure conflict in the mathematics and physics community that took place in the early 1890's between advocates of quaternions and proponents of the newer vector analysis. This conflict is tied in to major themes in the book, such as the tensions between the old and the emerging world that culminated in the conflict of World War I, and the ability to perceive and describe the world in more than the three dimensions of Euclidean space. Quaternions, like the luminiferous aether discussed in Part 1 of this essay, became superfluous and obsolete, mostly unnecessary in the efforts of physicists to describe the natural world after the advent of modern vector algebra and calculus.

A group of researchers has developed a novel way to view the world through the eyes of a common fly and partially decode the insect’s reactions to changes in the world around it.

The research fundamentally alters earlier beliefs about how neural networks function and could provide the basis for intelligent computers that mimic biological processes.

The researchers used tiny electrodes to tap into motion-sensitive neurons in the visual system of a common blowfly. Neurons are nerve cells that emit tiny electric spikes when stimulated. The electrodes detected pulses from the motion-sensitive neurons in the fly.

This week, NASA's Wilkinson Microwave Anisotropy Probe (WMAP) showed off three key findings contained in five years of data:

(1)New evidence that a sea of cosmic neutrinos permeates the universe

(2) Clear evidence the first stars took more than a half-billion years to create a cosmic fog

(3)Tight new constraints on the burst of expansion in the universe's first trillionth of a second

"We are living in an extraordinary time," said Gary Hinshaw of NASA's Goddard Space Flight Center in Greenbelt, Md. "Ours is the first generation in human history to make such detailed and far-reaching measurements of our universe."

U.S. Forest Service scientists believe an Oregon State University graduate student working on a cooperative project with the agency’s Pacific Southwest Research station on the Tahoe National Forest has photographed a wolverine, an animal whose presence has not been confirmed in California since the 1920s.

Katie Moriarty, a wildlife biology student, was conducting research on another carnivore called the American marten when a remote-controlled camera she set photographed the animal on February 28, 2008. Forest Service scientists who are experts at detecting rare carnivores believe the photographed animal is a wolverine.

The North American wolverine is the largest member of the weasel family. Adult males weigh 26 to 40 pounds, while females are 17 to 26 pounds.