Is there sex-specific epigenetic regulation of fear memory?
A new study says yes, for mice anyway, and if it later is found to be similar in humans it could explain why fear and stress-related disorders affect men and women differently.
Fear and memory produce changes to genes that modulate gene expression, called epigenetic modifications, some contend. In a mouse model of traumatic memory
, epigenetic activation of
gene important for creating fear memories and stress behavior, called cyclin dependent kinase 5 (Cdk5)
increased naturally in males, but not in females, after the mice recalled a fear-related memory.