COX-2 inhibitors are having a tough year. Vioxx was withdrawn voluntarily a few months ago and now Celebrex, the arthritis drug that blocks pain by inhibiting the COX-2 enzyme, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a pathway unrelated to its COX-2 inhibition.
University at Buffalo researchers discovered this unexpected finding while conducting basic research on potassium channels.
Celebrex (Celecoxib) has been taken by over 27 million patients since its approval by the FDA in 1998. The new research found that low concentrations of the drug, corresponding to a standard prescription, reduced the heart rate and induced pronounced arrhythmia in fruit flies and the heart cells of rats.