Ovarian cancer is the deadliest of all cancers affecting the female reproductive system with very few effective treatments available. Prognosis is even worse among patients with certain subtypes of the disease. Now, researchers at The Wistar Institute have identified a new therapeutic target in a particularly aggressive form of ovarian cancer, paving the way for what could be the first effective targeted therapy of its kind for the disease.

The findings were published online by the journal Nature Medicine.

Frequent menopausal vasomotor symptoms (VMS), including hot flashes and night sweats, lasted for more than seven years during the transition to menopause for more than half of the women in a large study and African American women reported the longest total VMS duration, according to a new study.

VMS are the hallmark of the menopausal transition and they can affect the quality of women's lives. Up to 80 percent of women experience VMS during the transition to menopause and, despite the pervasiveness of these symptoms, robust estimates about how long VMS last are lacking.

Picture this: For the past two weeks you have felt continuously dejected. You have lost interest in what normally makes you happy. Perhaps you’ve slept poorly or lost your appetite. There is a risk that you have one of the most common maladies in the world: Depression.

You decide to see a doctor. She considers different treatments and finally she gives you a prescription for a small box of antidepressants. Whether they will help you is unclear. Some patients report an effect after two or three weeks, others don’t notice any change at all. Some even get even more depressed.

More depressed? If it is actually a healthy person who doesn't have clinical depression, it's certainly possible. 

Measurements at BESSY II have shown how spin filters forming within magnetic sandwiches influence tunnel magnetoresistance - results that can help in designing spintronic components. In doing so, the teams enhanced our understanding of processes that are important for future TMR data storage devices and other spintronic components.

A study that assessed the impact of urban land use on the initiation of thunderstorms from 1997 to 2013 in the humid subtropical region of the southeast United States found that isolated convective initiation events occur more often over the urban area of Atlanta compared with its surrounding rural counterparts.

The findings confirm that human-induced changes in land cover in tropical environments lead to more thunderstorm initiation events.

Nicotine's primary metabolite supports learning and memory by amplifying the action of a primary chemical messenger involved in both, researchers report.

"This is the first hint of what the mechanism of the metabolite cotinine might be," said Dr. Alvin V. Terry, Chairman of the Department of Pharmacology and Toxicology at the Medical College of Georgia at Georgia Regents University and corresponding author of the study in the Journal of Pharmacology and Experimental Therapeutics.

While the findings show therapeutic promise for a metabolite once thought to be inactive, cotinine's benefits don't hold up across all learning and memory systems so Terry is already looking at analogues that would be even more broadly effective and equally safe.