Reporting in the Journal of Biological Chemistry, an international team of researchers has determined the structure of 14α-Demethylase (14DM), an enzyme essential to the survival of the protozoan parasites that cause sleeping sickness, Chagas disease and leishmaniasis. They say this new information provides the first up-close look at the busy enzyme and, perhaps more importantly, shows how one compound in particular prevents it from conducting business as usual.

The team chose to attack the parasite's enzyme known as 14DM because it has a counterpart in fungi, which cause athlete's foot and ringworm, and such fungal infections are commonly treated with drugs that prevent 14DM from making ergosterol, a sterol required for membrane synthesis.

Climate scientists predict increasing numbers of storms, droughts, floods and heat waves as the Earth warms, but the effects of these fluctuating conditions on biodiversity could actually go either way, according to recent ecological research. Species able to tolerate only a narrow range of temperatures, for example, may be eliminated, but instability in the environment can also prevent dominant species from squeezing out competitors.

Writing  in Nature Medicine, scientists from the Fred Hutchinson Cancer Research Center and the University of Washington say they have demonstrated how to increase the number of  progenitor cells capable of rapid myeloid engraftment after cord blood transplantation. The discovery clears a major technical hurdle to making umbilical-cord-blood transplants more widely available for treating leukemia and other blood cancers.

New insights about the scaly-foot gastropod, a tiny snail that lives near thermal vents on the floor of the indian ocean, could help scientists design better armor for soldiers and military vehicles, according to a new study appearing in PNAS.

MIT materials scientists report that the snail's shell is unlike any other naturally occurring or man made armor. Their study suggests that its unique structure dissipates energy that would cause weaker shells to fracture.

When a crab attacks a snail, it grasps the snail's shell with its claws and squeezes it until it breaks — for days if necessary. The claws generate mechanical energy that eventually fractures the shell, unless it is strong enough to resist.

Older people who suffer "mental lapses," or episodes when their thinking seems disorganized or illogical, may be more likely to develop Alzheimer's disease than people who do not have these lapses, according to a study published in the January 19, 2010, issue of Neurology.

These cognitive fluctuations, are common in a type of dementia called dementia with Lewy bodies, but researchers previously did not know how frequently they occurred in people with Alzheimer's disease and, equally important, what effect fluctuations might have on their thinking abilities or assessment scores.

Though it's commonly thought that most opioid overdoses occur among drug abusers and people who obtain the drugs illegally, a new study published in the Annals of Internal Medicine links the risk of fatal and nonfatal opioid overdose to prescription use—strongly associating the risk with the prescribed dose.