A researcher at MIT's Picower Institute for Learning and Memory has pinpointed stem cells within the spinal cord that, if persuaded to differentiate into more healing cells and fewer scarring cells following an injury, may lead to a new, non-surgical treatment for debilitating spinal-cord injuries.

The work in PLoS Biology is by Konstantinos Meletis, a postdoctoral fellow at the Picower Institute, and colleagues at the Karolinska Institute in Sweden. Their results could lead to drugs that might restore some degree of mobility to the 30,000 people worldwide afflicted each year with spinal-cord injuries.

In a developing embryo, stem cells differentiate into all the specialized tissues of the body. In adults, stem cells act as a repair system, replenishing specialized cells, but also maintaining the normal turnover of regenerative organs such as blood, skin or intestinal tissues.

An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in PNAS. The protein, HMGB1, was previously hypothesized to block DNA repair, senior author Karen Vasquez, Ph.D., associate professor in M. D. Anderson's Department of Carcinogenesis at the Science Park - Research Division in Smithville, Texas.

Identification and repair of DNA damage is the frontline defense against the birth and reproduction of mutant cells that cause cancer and other illnesses.

Pinpointing HMGB1's role in repair raises a fundamental question about drugs under development to block the protein, Vasquez said. The protein also plays a role in inflammation, so it's being targeted in drugs under development for rheumatoid arthritis and sepsis.

Carbon dioxide has been getting a bad rap for the last few years, what with "Waterworld" and the IPCC's preference for French nuclear plants, but laser resurfacing appears to be an effective long-term treatment for facial wrinkles, according to a report in the July/August issue of Archives of Facial Plastic Surgery. So at least aging rich women will look good when the planet dies.

The carbon dioxide laser vaporizes water molecules inside and outside of cells, causing thermal damage to the surrounding tissue, the authors write as background information in the article. In response to this insult, the skin produces more of the protein collagen, which fills in wrinkles. "In addition to structural changes, the healing process frequently leads to pigmentary [coloring] changes," the authors write. "These changes in skin pigmentation may be desirable, such as when patients wish to remove solar evidence of aging; however, changes in pigmentation after treatment can often be a troubling adverse effect."

After completing one of the longest running experiments ever done on a lake, researchers from the University of Alberta, University of Minnesota and the Freshwater Institute, contend that nitrogen control, in which the European Union and many other jurisdictions around the world are investing millions of dollars, is not effective and in fact, may actually increase the problem of cultural eutrophication.

The dramatic rise in cultural eutrophication—the addition of nutrients to a body of water due to human activity that often causes huge algal blooms, fish kills and other problems in lakes throughout the world—has resulted from increased deposits of nutrients to lakes, largely from human sewage and agricultural wastes.

If you really love the outdoors, you should never experience it, according to a new study by conservation biologists from the University of California, Berkeley.

The study compared parks in the San Francisco Bay Area that allow only quiet recreation such as hiking or dog walking with nearby nature reserves that allow no public access. Evidence of some native carnivore populations - coyote and bobcat - was more than five times lower in parks that allow public access than in neighboring reserves where humans don't tread, the researchers report.

The dearth of these animals in the parks carries implications beyond just these species. Since the carnivores in the study are often the top predators in their areas, these animals also shape the rest of their surrounding ecosystems. The flight of large animals from heavily visited parks for more serene surroundings could, in turn, influence populations of small animals and plants, the researchers said.

Elvira Fortunato and colleagues from the Centro de Investigação de Materiais (Cenimat/I3N), at Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, made the first Field Effect Transistor (FET) with a paper «interstrate» layer.

There is an increased interest in the use of biopolymers for low-cost electronic applications. Since cellulose is the Earth’s major biopolymer, some international teams have reported using paper as the physical support (substrate) of electronic devices but no one had used paper as an interstrate component of a FET.

The electrical performance of the new device rivals oxide-based thin film transistors (TFTs) produced on glass or crystalline silicon substrates. Full results will be published in September's in IEEE Electron Device Letters.