Why would humans evolve allergy problems? A team from the Randall Division of Cell & Molecular Biophysics, King's College London are working on a molecule vital to the chicken's immune system which represents the evolutionary ancestor of the human antibodies that cause allergic reactions.

Crucially, they have discovered that the chicken molecule behaves quite differently from its human counterpart, which throws light on the origin and cause of allergic reactions in humans and gives hope for new strategies for treatment.

The chicken molecule, an antibody called IgY, looks remarkably similar to the human antibody IgE. IgE is known to be involved in allergic reactions and humans also have a counterpart antibody called IgG that helps to destroy invading viruses and bacteria. Scientists know that both IgE and IgG were present in mammals around 160 million years ago because the corresponding genes are found in the recently published platypus genome. However, in chickens there is no equivalent to IgG and so IgY performs both functions.

Every year, about 500 million people worldwide are infected with the parasite that causes dysentery, a global medical burden that among infectious diseases is second only to malaria. In a new study appearing in the June 15 issue of Genes and Development, Johns Hopkins researchers may have found a way to ease this burden by discovering a new enzyme that may help the dysentery-causing amoeba evade the immune system.

"This is the first enzyme to be identified that looks like it could mediate immune system evasion," says Sin Urban, Ph.D., an assistant professor of molecular biology and genetics at Hopkins.

The EhROM1 enzyme, it turns out, is part of an ancient group of enzymes—they are found in every branch of life from bacteria to man—known as rhomboid enzymes. In most animals, rhomboid enzymes seem to play a role in cell-to-cell communication, but a couple of years ago Urban found that malaria parasites use rhomboid enzymes for a more sinister purpose: to enter host cells uninvited.

It's an urban legend we've all read - you meet some nice girl in Thailand and you black out and wake up in a bathtub without a kidney.

Kidneys, and other replaceable organs, have value because the wait list is long and someone has to die to donate them.

Arthur Matas, Professor of Surgery at the University of Minnesota, writing in this week's BMJ says a regulated system of compensation for living donors may be the solution to the growing shortage of kidneys for transplantation.

But Jeremy Chapman, from the Centre for Transplant and Renal Research in Sydney, argues that this could reduce the supply of all organs. He believes that the idea of the regulated market is a myth, which could have devastating consequences on the less easily regulated environments of Asia and Africa.

New evidence that chemical contaminants are finding their way into the deep-sea food web has been found in deep-sea squids and octopods, including the strange-looking "vampire squid". These species are food for deep-diving toothed whales and other predators.

In a study to be published in the journal Marine Pollution Bulletin, Michael Vecchione of NOAA Fisheries' National Systematics Laboratory and colleagues Michael Unger, Ellen Harvey and George Vadas at the Virginia Institute of Marine Science of The College of William and Mary report finding a variety of chemical contaminants in nine species of cephalopods, a class of organisms that includes octopods, squids, cuttlefishes and nautiluses.

Cephalopods are important to the diet of cetaceans, a class of marine mammals which includes whales, dolphins and porpoises. Cephalopods are the primary food for 28 species of odontocetes, the sub-order of cetaceans that have teeth and include beaked, sperm, killer and beluga whales and narwhals as well as dolphins and porpoises.

Fragile X syndrome (FXS) robs the brain of a protein that plays a major role in the way neurons communicate and that is essential for brain development, learning and memory.

A team of scientists has discovered new information about how FXS interferes with signaling between the nucleus of neurons and the synapse, the outer reaches of the neuron where two neurons communicate via chemical and electrical signals. The discovery should help lead the way to the development of new treatments for FXS, the most common form of inherited mental retardation and also a genetic contributor to some types of autism and epilepsy.

Translation of an organism's genetic information begins in the nucleus of a cell, where the DNA sequence (gene) is copied into an mRNA molecule, then exported into the cell's cytoplasm and translated into protein molecules.

An important component of early genetic material found in meteorite fragments is extraterrestrial in origin, say scientists from Europe and the USA. They say their research in Earth and Planetary Science Letters provides evidence that life’s raw materials came from sources beyond the Earth.

The materials they have found include the molecules uracil and xanthine, which are precursors to the molecules that make up DNA and RNA, and are known as nucleobases. The team discovered the molecules in rock fragments of the Murchison meteorite, which crashed in Australia in 1969.

They tested the meteorite material to determine whether the molecules came from the solar system or were a result of contamination when the meteorite landed on Earth. The analysis shows that the nucleobases contain a heavy form of carbon which could only have been formed in space. Materials formed on Earth consist of a lighter variety of carbon.