A team of researchers at Chalmers University of Technology has found that kidney cancer cells have a quite different metabolism than other types of malignancies. The findings pave the way for new methods of diagnosing kidney cancer at an early stage, a feat that had eluded researchers earlier, and thereby fresh approaches to treatment.

Cancer is a result of mutations in the genes of healthy cells. The transition to cancer cells involves a fundamental transformation of their metabolism, the way that they use nourishment and energy. The uninhibited growth of cancer cells is based on their particular metabolism.

A pre-clinical study led by Virginia Commonwealth University Massey Cancer Center and Department of Internal Medicine researchers suggests that an experimental drug known as dinaciclib could improve the effectiveness of certain multiple myeloma and myeloid leukemia therapies. The study, recently published in the journal Molecular Cancer Therapeutics, showed that dinaciclib disrupted a cell survival mechanism known as the unfolded protein response (UPR). Without the UPR, multiple myeloma and myeloid leukemia cells were unable to combat damage caused by some anti-cancer agents.

BLOOMINGTON -- A new Indiana University study that examines the brain activity of alcohol-dependent women compared to women who were not addicted found stark and surprising differences, leading to intriguing questions about brain network functions of addicted women as they make risky decisions about when and what to drink.

The study used functional magnetic resonance imaging, or fMRI, to study differences between patterns of brain network activation in the two groups of women. The findings indicate that the anterior insular region of the brain may be implicated in the process, suggesting a possible new target of treatment for alcohol-dependent women.

The first life developed in ancient oceans some 3.6 billion years ago, but then nothing much happened. For a billion years, we remained pretty much a layer of slime. 

Then 550 million years ago, evolution came roaring back and here we are today. So what was the hold-up during a billion boring years?

According to University of Tasmania geologist Professor Ross Large and colleagues, the key was a lack of oxygen and nutrient elements, which placed evolution in a precarious position. "During that billion years, oxygen levels declined and the oceans were losing the ingredients needed for life to develop into more complex organisms."

How accurately can you simulate the universe's most violent events?

Enrico Ramirez-Ruiz wanted to find out, so when the first detailed observations of a star being ripped apart by a black hole were reported in 2012 (Gezari et al., Nature), he was eager to compare the data with his numerical model.

He was also highly skeptical of one of the published conclusions: that the disrupted star was a rare helium star. 

"I was sure it was a normal hydrogen star and we were just not understanding what's going on," said Ramirez-Ruiz, a professor of astronomy and astrophysics at the University of California, Santa Cruz.

Primary care doctors are not quick to prescribe antihypertensive medication to young people even after an average of 20 months of high blood pressure. Young adults who are white, male, not on Medicaid and not frequent clinic visitors are especially less likely to receive medication. These are the results of a study¹ by a research team at the University of Wisconsin School of Medicine and Public Health in the United States led by Heather Johnson. It appears in the Journal of General Internal Medicine², published by Springer.