NASHVILLE, Tenn. – To develop correctly, baby hearts need rhythm...even before they have blood to pump.

"We have discovered that mechanical forces are important when making baby hearts," said Mary Kathryn Sewell-Loftin, a Vanderbilt graduate student working with a team of Vanderbilt engineers, scientists and clinicians attempting to grow replacement heart valves from a patient's own cells.

In an article published last month in the journal Biomaterials the team reported that they have taken an important step toward this goal by determining that the mechanical forces generated by the rhythmic expansion and contraction of cardiac muscle cells play an active role in the initial stage of heart valve formation.

We tend to think of antibiotic resistance as a product of modern medicine and the mutation ability of pesky viruses to get around dying.

Writing in the journal Applied and Environmental Microbiology, a team of investigators say they have discovered viruses containing genes for antibiotic resistance in a fossilized fecal sample from 14th century Belgium, long before antibiotics were used in medicine. 

The widespread loss of forest to sugarcane fields on the island of Mauritius has forced kestrels living there to survive by speeding up their life histories, according to a report published online on February 20 in the Cell Press journal Current Biology. By getting an earlier start, the birds are managing to have just as many offspring, even though they die sooner.

Those changes to the kestrels' life history are apparently driven entirely by their early life experiences, the researchers say.

JUPITER, FL, February 20, 2014 – The use of antibiotics is often considered among the most important advances in the treatment of human disease. Unfortunately, though, bacteria are finding ways to make a comeback. According to the Centers for Disease Control, more than two million people come down with antibiotic-resistant infections annually, and at least 23,000 die because their treatment can't stop the infection. In addition, the pipeline for new antibiotics has grown dangerously thin.

Now, a new study by scientists from the Florida campus of The Scripps Research Institute (TSRI) has uncovered a mechanism of drug resistance. This knowledge could have a major impact on the development of a pair of highly potent new antibiotic drug candidates.

University of Colorado Boulder scientists have found a creative way to radically improve thermoelectric materials, a finding that could one day lead to the development of improved solar panels, more energy-efficient cooling equipment, and even the creation of new devices that could turn the vast amounts of heat wasted at power plants into more electricity.

The technique—building an array of tiny pillars on top of a sheet of thermoelectric material—represents an entirely new way of attacking a century-old problem, said Mahmoud Hussein, an assistant professor of aerospace engineering sciences who pioneered the discovery.

ROCHESTER, Minn. — Feb. 20, 2014 — Researchers say the discovery of how sodium ions pass through the gill of a zebrafish may be a clue to understanding a key function in the human kidney. The findings from a collaboration between Mayo Clinic and the Tokyo Institute of Technology appear in the online issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

The researchers discovered a protein responsible for gas exchanges in the fish gill structure. Specifically they studied and characterized the Na+/H+ (sodium/hydrogen) exchanger named NHE3, responsible for controlling sodium and hydrogen ions across the gill. The researchers also directly demonstrated that NHE3 can function as a Na+/NH4+ (sodium/ammonium) exchanger.