Researchers at the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) have made the discovery that tuberculosis and leprosy bacteria follow a different path into the host cell than that which for forty years scientists had always maintained.

The insight has huge implications for an understanding of these diseases and for more effective medicines to combat TB, leprosy and even cervical cancer.

High-resolution electron microscopes and tomography have enabled Peters, Van der Wel and their colleagues to map the cell's internal organisation. Knowledge of differing cell organelles that also play a role in the development of cancer is important when trying to understand fundamental cell processes.

Researchers from the European Molecular Biology Laboratory now reveal that the hypothalamus and its hormones are not purely vertebrate inventions, but have their evolutionary roots in marine, worm-like ancestors.

Hormones control growth, metabolism, reproduction and many other important biological processes. In humans, and all other vertebrates, the chemical signals are produced by specialized brain centers such as the hypothalamus and secreted into the blood stream that distributes them around the body.

Hormone-secreting brain centers are much older than expected and likely evolved from multifunctional cells of the last common ancestor of vertebrates - flies and worms.

The so-called Ret Chip, the world's first genetic chip to be produced for diagnosing hereditary diseases of the retina in a genetic examination, will become available in mid-July. The chip is the largest to be used to date for the diagnosis of human hereditary disorders. It was developed by a team of scientists headed by Professor Bernhard Weber at the Institute for Human Genetics at the University Hospital Regensburg.

In Europe roughly one child in 4,000 is born with a hereditary retina disorder. The most common disorder is retinitis pigmentosa, of which there are a number of different variants. Although ophthalmologists can diagnose the destruction of nerve cells in the retina, in most cases they can’t offer patients any treatment.

The core of the gaming industry has always been young men with plenty of free time but increasingly investors and developers are trying to attract the casual gamers, including women, who have less time and infrequent contiguous blocks but are still interesting in being part of the gaming experience.

This new genre is called ‘casual games’ and is attracting players from all around the world. "These new games are quick to learn and the focus is on fun rather than on making the games difficult or time consuming", explains lecturer Jesper Juul, who has through his research placed a focus on computer game design at the IT University of Copenhagen.

It's long been known that a woman's chance of getting breast cancer is related to family medical history.

It turns out that surviving it may also be inherited. Research published in the online journal Breast Cancer Research suggests that if a woman succumbs to breast cancer her daughters or sisters are over 60 percent more likely to die within five years if they develop the disease.

A research team including University of Central Florida Microbiology Professor Keith Ireton is using the bacterial pathogen Listeria Monocytogenes to understand the mechanisms of cell growth and cancer development.

In research published this month in the Journal of Biological Chemistry, the team found that a Listeria protein called InlB induces internalization and degradation of a human receptor known as Met. Met has been implicated in the development of some cancers.