Researchers have long-known that visceral fat - the kind that wraps around the internal organs - is more dangerous than subcutaneous fat that lies just under the skin around the belly, thighs and rear. But how visceral fat contributes to insulin resistance and inflammation has remained unknown.

A study led by researchers at the University of Illinois at Chicago points blame at a regulatory molecule in cells called TRIP-Br2 that is produced in response to overeating's stress on the machinery cells use to produce proteins.

The findings are published in the journal Nature Communications.

Isotretinoin (popularly marketed as Accutane) is used to treat severe acne and has been approved in Canada since 1983. The average age of isotretinoin users in Canada is estimated to be 24 years, and half of all prescriptions are written for females, a concern because it can severely harm a fetus, causing craniofacial, cardiac and central nervous system defects, as well as a high likelihood of miscarriage or medical termination. 

Even Canada's program recommends informed written consent, two negative pregnancy tests before beginning treatment and the use of two reliable birth control methods during treatment, numerous studies in Canada and internationally have indicated poor adherence to pregnancy prevention guidelines among women taking isotretinoin. 

Some new speculation on animal (metazoan) evolution, suggesting that it was partly mediated through a biochemical oscillator (cycler), named Life's Timekeeper, present in all animal cells. The cycler controls cell maintenance and repair, thereby determining how long cells survive (longevity) and it originated in the single-celled ancestor of all animals, which had very short cell longevity.

AUGUSTA, Ga. - Low levels of vitamin D in black teens correlates with low activity of a major mechanism for controlling gene expression that may increase their risk of cancer and other disease, researchers report.

Their study measured vitamin D levels as well as levels of global DNA methylation in 454 healthy individuals age 14-18. In this group, 99 percent of the white teens had adequate vitamin D levels, 66 percent of the black teens were vitamin D-deficient and all the black teens had lower levels of methylation compared to their white peers, said Dr. Haidong Zhu, molecular geneticist at the Georgia Prevention Institute at the Medical College of Georgia at Augusta University.

Athens, Ga. - Over the past several decades, scientists have observed a significant increase in the melting of glacial land ice on the island of Greenland, spurring concerns about global sea level rise and the long-term effects of atmospheric warming. What has been less clear, however, is what happens to this meltwater once it enters the ocean.

Now, a team of researchers led by faculty at the University of Georgia has discovered the fate of much of the freshwater that pours into the surrounding oceans as the Greenland ice sheet melts every summer. They published their findings today in the journal Nature Geoscience.

"Black Monday" has become as much a part of the National Football League season as Draft Day. The Monday after the last game of the season is marked by the firing of a number of head coaches and the start of a frenetic search for new ones. Many NFL teams searching for a coach rely on "coaching trees" and turn to assistants of highly successful head coaches.

Craig Crossland, a professor of management in the University of Notre Dame's Mendoza College of Business, and his colleagues studied the NFL to determine if the so-called "acolyte effect" that makes protégés of successful head coaches successful in turn is real. They tracked the career outcomes of almost 1,300 coaches over 30 years.