Results of the Wellcome Trust funded trial of the experimental anti-Ebola drug TKM-130803 have been published today (April 19) in PLOS Medicine. Using a novel approach designed to get rapid indications of a drug's effectiveness, the trial showed that at the dose given the drug did not improve survival compared to historic controls.

CAMBRIDGE, MA -- Jeffrey Grossman thinks we've been looking at coal all wrong. Instead of just setting it afire, thus ignoring the molecular complexity of this highly varied material, he says, we should be harnessing the real value of that diversity and complex chemistry. Coal could become the basis for solar panels, batteries, or electronic devices, he and his research team say.

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment. This is the main finding of a study led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center to be presented April 19 in New Orleans at the annual meeting of the American Association for Cancer Research.

Pancreatic cancer patients are known to be susceptible to gum disease, cavities, and poor oral health in general, say the study authors. That vulnerability led the research team to search for direct links between the makeup of bacteria driving oral disease and subsequent development of pancreatic cancer, a disease that often escapes early diagnosis and causes 40,000 US deaths annually.

The difficulty in subduing the pandemic strain of drug-resistant E. coli, called H30, may go beyond patient vulnerability or antibiotic resistance. This form of the disease-pathogen may have an intrinsic ability to cause persistent, harmful, even deadly infections.

The bacterium E. coli comes in many different varieties. Many strains live unobtrusively in the gut or innocuously in the environment. Some strains can cause diarrhea. Others can invade the urinary tract, the blood stream, or other parts of the body to provoke varying degrees of illness, from mild to serious and sometimes fatal.

DURHAM, N.C. -- Humans aren't alone in their ability to mix perfumes and colognes. Lemurs, too, get more out of their smelly secretions by combining fragrances to create richer, longer-lasting scents, finds a study led by Duke University.

The results appear online April 20 in Royal Society Open Science.

The "perfume" of the ring-tailed lemur could never be confused with Chanel. Male ring-tailed lemurs, our distant primate cousins, produce their distinctive musky odor with help from a pair of glands on their wrists that give off droplets of clear, fast-evaporating fluid, and a second pair of glands on their chests that secrete a brown, foul-smelling paste.

• GPS tool has pinpointed origin of Yiddish speakers