The first animal model for ALS dementia, a form of ALS that also damages the brain, has been developed. This advance will allow researchers to directly see the brains of living mice, under anesthesia, at the microscopic level and will allow direct monitoring of test drugs to determine if they work. 

Within the first 5 years after the birth of a child, women are considered at an increased risk of developing metastatic breast cancer.

Why that happens has been considered a puzzle but the fact remains that women diagnosed with postpartum breast cancer have a decreased disease free survival time compared to women that have never given birth.

The aggressive tendency of postpartum breast cancer suggests that the post-birth breast environment promotes tumor metastasis. A new study in the Journal of Clinical Investigation, suggests that dying tumor cells in postpartum breast tissue promote metastatic disease.

Stroke is one of the leading causes of death worldwide and while there are obvious environmental factors such as diet, exercise and behavior, many lines of evidence suggest that the risk of stroke is heritable. Yet until now, only a small number of genes associated with stroke have been identified. 

A new study in the Journal of Clinical Investigation identifies two genes that underlie cerebral small-vessel disease (CSVD), a risk factor for stroke.

Ordan Lehmann and colleagues at the University of Alberta analyzed genome-wide association data from individuals that received brain MRI scans as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) study.

In the developed world, people are having fewer children and living longer and that has led to a population that is older than in the past.

On average, life expectancy in developed countries has risen at a pace of three months per year, and fertility has fallen below replacement rate in the majority of Europe and some other developed countries. Most academic discussion of this trend has so far focused on potential problems - when social security was young there were over 20 workers per retiree and now there are 3 - and that is without the entire Baby Boom being retired and incurring healthcare costs.

Ovarian cancer is the most deadly gynecological kind, it claims the lives of more than 50% of women who are diagnosed

Ovarian cancer is often diagnosed late and develops a resistance to chemotherapy but new insight into why may lead to better diagnosis and treatment.

Retinoblastoma is a childhood retinal tumor usually affecting children ages one to two and the most common malignant tumor of the eye in children. Left untreated, retinoblastoma can be fatal or result in blindness.

Retinoblastomas have been found to develop in response to the mutation of a single gene, the RB1 gene, demonstrating that some cells are only a step away from developing into a life-threatening malignancy.