About Maria MRes in Biomolecular sciences at the University of York, 2003. BSc in Applied Biochemistry and Molecular Biology at the University of the West of England, Bristol, 2001 Research Experience: 2003-2005 Marie-Curie Fellowship by the Research Training Network. Laboratory of 'Receptors and Cognition', whose director is Professor Jean-Pierre Changeux, at the Pasteur Institute in Paris, France, from 1/10/2004 to 1/10/2005. Topic: ‘Modelling studies of the binding of Cobratoxin to the nAChR at the atomic level’. Knowledge acquired on: UNIX/LINUX, protein-protein docking methodology, use of the 3D-Dock protein-protein docking software and of VMD and SPDBV molecular visualisation software. Training course at the Fleming Institute Publications 2009 1) Nikou D., Malandrakis A., Markoglou A., Konstantakaki M., Vontas J. and Ziogas V. Molecular characterization and detection of overexpressed C-14 demethylase-based DMI resistance in Cercospora beticola field isolates from Greece. Journal of Pesticide Biochemistry and Physiology (2009) Vol. 95, No. 1, pp. 18-27. 2) Nikou D., Konstantakaki M., Malandrakis A., Vontas J. and Ziogas V. Characterization of an altered C-14 demethylase-based DMI resistance in Cercospora beticola (in prep). 2008 3) Maria Konstantakaki, Socrates J. Tzartos, Konstantinos Poulas and Elias Eliopoulos. Model of the extracellular domain of the human α7 nAChR based on the crystal structure of the mouse α1 nAChR extracellular domain. Journal of Molecular Graphics and Modelling (2008) Jun;26(8):1333-7. 4) Nagy, V., Felf ldi, N., Praly, J.-P., Docsa, T., Gergerly, P., Chrysina, E.D., Tiraidis, C., Kosmopoulou, M.N., Alexacou, K.-M., Konstantakaki, M. N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation ( To be Published). 2007 5) Maria Konstantakaki, Socrates J. Tzartos, Konstantinos Poulas and Elias Eliopoulos. Molecular modeling of the complex between Torpedo acetylcholine receptor and anti-MIR Fab198. Biochem Biophys Res Commun. (2007) May 11;356(3):569-75. 6) Maria Konstantakaki, Jean-Pierre Changeux, Antoine Taly. Docking of α-cobratoxin suggests a basal conformation of the nicotinic receptor. Biochem Biophys Res Commun. (2007) June 4; 359:413-418. 7) CHRISTOS TSIGRIS, MARIA KONSTANTAKAKI, CONSTANTINOS XIROMERITIS, NIKOLAOS NIKITEAS and ATHANASSIOS YANNOPOULOS. Review: Animal Models of Carcinogenesis in the Digestive System. In Vivo. (2007) Sep-Oct;21(5):803-12. Research communications -Chrysina, E.D., Kosmopoulou, M.N., Konstantakaki, M.E., Leonidas, D.D., Nagy, V., Somsak L., Gergel P. & Praly, J-P. (2002). Structural studies on N-b-D glucopyranosyl urea analogues in complex with glycogen phosphorylase b. Protein Crystallography on EMBL Beamlines, EMBL Hamburg Synchrotron Annual Report. Conferences-Posters 2008 - Poster presentation at the 3rd confenrence: Computational Biology and Bioinformatics Society in Greece, 30-31 October 2008, Αθήνα. Poster title: “Modelling studies on the nicotinic acetylcholine receptor”. M. Konstantakaki, S. Tzartos, K. Poulas and E. Eliopoulos. - Poster presentation at the 4th conference of the Hellenic Crystallographic Society, 26-27 September 2008, Αθήνα. Poster title: “Modelling studies on the nicotinic acetylcholine receptor”. M. Konstantakaki, S. Tzartos, K. Poulas and E. Eliopoulos. - Participation to the 33rd FEBS-11th IUBMB conference (28 of June to 3rd of July 2008, Athens) with scholarship from the Hellenic Society of Biochemistry and Molecular Biology. Poster title: Homology Modelling of α7 nicotinic acetylcholine receptor. M. Konstantakaki, S. Tzartos, K. Poulas and E. Eliopoulos. - Poster presentation at the 6th Peptide Forum at the University of Patras that is organised by professor P. Kordopatis (18th to 20th May 2008). Title: Homology modeling, expression and characterization of α7 Acetylcholine receptor polypeptides. K. Poulas, M. Zouridakis, P. Zisimopoulou, M. Konstantakaki, P. Giastas, A. Sotiriadis, A. Niarchos, E. Eliopoulos, S. J. Tzartos. - Poster presentation at the Nicotinic Acetylcholine Receptors 2008 conference (23rd to 26th of April, 2008). Title: Novel mutations of α7 nAChR extracellular domain, based on homology modeling. P. Zisimopoulou, M. Zouridakis, M. Konstantakaki, A. Sotiriadis, P. Giastas, I. Papadaki, A. Niarchos, I. Gavra, K. Poulas, E. Eliopoulos, S. J. Tzartos. 2006 -Award of MGMS grant for poster presentation and participation at the “Quantum Pharmacology 30 Years’ On meeting. The title of the poster was: “Model Immunocomplex of Torpedo Nicotinic Acetylcholine Receptor and Fab198 Murine Antibody”. Maria Konstantakaki, Socrates J. Tzartos, Konstantinos Poulas and Elias Eliopoulos. -Accelrys, EU Science Forum 2006 Poster presentation. -14èmes Rencontres en Toxinologie: "Toxins et Cancer", Paris, 30 Novembre-1er Décembre, 2006. Poster Title: Models for the complexes between nicotinic acetylcholine receptors and alpha-neurotoxins. Maria KONSTANTAKAKI, Jean-Pierre CHANGEUX, Antoine TALY. 2005 -Poster presentation, EU-RTN grant, at the MGMS International Meeting, ‘Biomolecular Simulations from prediction to practice’, held in Trinity College Dublin between the 11th and the 14th of September 2005. The title of the poster was: “Modelling studies of Cobratoxin binding to the nAChR at the atomic level”. Maria KONSTANTAKAKI, Jean-Pierre CHANGEUX, Antoine TALY. -Presentation of the results of the project: “Modelling studies of Cobratoxin binding to the nAChR at the atomic level”, EU-RTN grant, in the laboratory of Receptors and Cognition of Professor J.-P. Changeux, at the NIDE meetings held in Milan on 5/11/2004 and on 28/10/2005. 2004-2005 -Seminar by the College of France on 'Signal Transduction- Molecules of Central and peripheral action.' -Seminars of the Departments of 'Structural Biology and Chemistry' and 'Receptors and Cognition' at the Pasteur Institute in Paris. 2003-2004 -‘EMBO workshop on Biomolecular simulation’ between the 15th and 28th of July 2004, Pasteur Institute, Paris, France. Grant from the European Molecular Biology Organisation (ΕMBO), -18th meeting of the Hellenic society for Neuroscience, 17-19 October 2003, at the Hellenic Pasteur Institute. -'Demokritos' and 'Fleming' institute seminars on molecular biology and genetics, Greece. -55th Hellenic Biochemical and Molecular Biology society meeting at the Academy of Athens, Greece. 1/2002 -Collaborative Computational Project in Macromolecular Crystallography (CCP4) and Daresbury Laboratory meeting on High-throughput structure determination, University of York, York, UK

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