In what they call a “stunning research advance,” investigators at Georgetown University Medical Center have been able to use simple, non-toxic chemical injections to add and remove fat in targeted areas on the bodies of laboratory animals.

They say the discovery could revolutionize human cosmetic and reconstructive plastic surgery and treatment of diseases associated with human obesity.

Investigators say these findings may also, over the long-term, lead to better control of metabolic syndrome, which is a collection of risk factors that increase a patient’s chances of developing heart disease, stroke, and diabetes.

In the last 40 years, scientists have perfected ways to determine the knot-like structure of enzymes, but they’ve been stumped trying to translate the structure into an understanding of function – what the enzyme actually does in the body. This puzzle has hindered drug discovery, since many of the most successful drugs work by blocking enzyme action.

Variations in the WFS1 gene, known to affect both the survival and function of insulin-producing cells in the pancreas, can be linked to type 2 diabetes susceptibility, according to a new study from Cambridge.

The study has two major implications – it identifies a new risk factor in a disease reaching epidemic levels worldwide while also showing that variations in a gene – and not only mutations – can lead to type 2 diabetes.

Ongoing field trials since 2002 by a team that includes 16 farmers, Cornell researchers and Cornell Cooperative Extension field crops educators in 10 counties are showing the value of on-farm research. Their results are successfully quantifying and predicting the nitrogen needs for growing corn, saving farmers money and reducing environmental impact.

"With this program, we focus on determining under what situations extra nitrogen would be good to add and when a farmer can save money by reducing fertilizer applications without impacting yield and quality," says Quirine Ketterings, associate professor of crop and soil sciences, who co-leads the research team.

Early use of new DNA sequencing technology enables scientists to create whole genome maps of chromatin in embryonic stem cells and other cells

As a fertilized egg develops into a full grown adult, mammalian cells make many crucial decisions — closing doors of opportunity as they adopt careers as liver cells, skin cells, or neurons. One of the most fundamental mysteries in biomedicine is how cells make such different career decisions despite having exactly the same DNA. By using a new kind of genomic technology, a new study unveils a special code — not within DNA, but within the so-called “chromatin” proteins surrounding it — that could unlock these mysterious choices underlying cell identity.

Researchers at the Salk Institute for Biological Studies have developed a novel strategy to expand the natural repertoire of 20 amino acids in mammalian cells, including neurons, and successfully inserted tailor-made amino acids into proteins in these cells. In a powerful demonstration of the method’s versatility, they then used unnatural amino acids to determine the operating mechanism of the “molecular gates” that regulate the movement of potassium ions in and out of nerve cells.

“In the past, this type of engineering has been mainly restricted to bacteria or in yeast, and it was very challenging to efficiently incorporate unnatural amino acids in mammalian cells.

Professor Herbert Herzog, Director of the Neuroscience Research Program at the Garvan Institute of Medical Research, together with scientists from the US and Slovakia, have shown that neuropeptide Y (NPY), a molecule the body releases when stressed, can ‘unlock’ Y2 receptors in the body’s fat cells, stimulating the cells to grow in size and number. By blocking those receptors, it may be possible to prevent fat growth, or make fat cells die.

“We have known for over a decade that there is a connection between chronic stress and obesity,” said Professor Herzog. “We also know that NPY plays a major role in other chronic stress-induced conditions, such as susceptibility to infection.

A just published scientific study conducted by researchers at the University of Miami School of Nursing in conjunction with The Sirkin Creative Living Center (SCLC) has found that Rescue Remedy®, an all-natural remedy created from flower essences, is an effective over-the-counter stress reliever with a comparable effect to traditional pharmaceutical drugs yet without any of the known adverse side effects, including addiction.

A role for prion proteins, the much debated agents of mad cow disease and vCJD, has been identified. It appears that the normal prions produced by the body help to prevent the plaques that build up in the brain to cause Alzheimer’s disease. The possible function for the mysterious proteins was discovered by a team of scientists led by Medical Research Council funded scientist Professor Nigel Hooper of the University of Leeds.

Alzheimer’s and diseases like variant Creutzfeldt-Jakob Disease follow similar patterns of disease progression and in some forms of prion disease share genetic features. These parallels prompted Professor Hooper’s team to look for a link between the different conditions. They found an apparent role for normal prion proteins in preventing Alzheimer’s disease.

Technical advances over the past 50 years have allowed improved knowledge to be gained of the properties of sea water at great depths. Yet the first centimetres of the ocean remain its least well known part. They are difficult to sample and study owing to the mixing the oceanographic vessel provokes between this superficial layer and the deeper strata of water. Nevertheless, a whole ecosystem exists within this layer, carrying numerous living organisms like bacteria, zooplankton and larger animals such as flying fish, which feed and reproduce in it.